New <scp>multitarget</scp> directed <scp>benzimidazole‐2‐thiol‐based</scp> heterocycles as prospective <scp>anti‐radical</scp> and <scp>anti‐Alzheimer</scp>'s agents

Latif, Abdul; Bibi, Samina; Ali, Sardar; Ammara, Ammara; Ahmad, Manzoor; Khan, Ajmal; Al‐Harrasi, Ahmed; Ullah, Farhat; Ali, Mumtaz

doi:10.1002/ddr.21740

Cited by 15 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-Alzheimer's agents [192]- [194], Angiotensin II -AT1 Receptor Antagonist [195]- [200], Antiulcer activity [201]- [204], Anti-Tubercular activity [205]- [211],…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…In addition to the above medical applications, benzimidazole derivatives have been widely used as an essential part of biological applications including: antihypertensive activity, 154 155 156 157 158 antiprotozoal activity, 159–163 antiviral activity, 164–167 anthelmintic activity, 168 169 170 171 172 antidiabetic agents, 173 174 175 176 177 analgesic activity, 78 , 178 179 180 181 antispasmodic activity, 182 183 antidepressant activity, 184 185 186 187 188 189 sphingosine kinase 1 inhibitor, 190 191 anti-Alzheimer’s agents, 192 193 194 angiotensin II-AT1 receptor antagonists, 195 196 197 198 199 200 antiulcer activity, 201 202 203 204 anti-tubercular activity, 205 206 207 208 209 210 211 anti-HIV agents, 212 213 214 215 216 217 218 and anti-secretory activity. 219 220 221…”

Section: Biological Activity Of Benzimidazole Derivativesmentioning

confidence: 99%

“…In addition to the above medical applications, benzimidazole derivatives have been widely used as an essential part of biological applications including: antihypertensive activity, [154][155][156][157][158] antiprotozoal activity, [159][160][161][162][163] antiviral activity, [164][165][166][167] anthelmintic activity, [168][169][170][171][172] antidiabetic agents, [173][174][175][176][177] analgesic activity, 78,[178][179][180][181] antispasmodic activity, 182,183 antidepressant activity, [184][185][186][187][188][189] sphingosine kinase 1 inhibitor, 190,191 anti-Alzheimer's agents, [192][193][194] angiotensin II-AT1 receptor antagonists, [195][196][197][198]…”

Section: Other Biological Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Alheety,

Mohammed,

Farhan

et al. 2023

SynOpen

View full text Add to dashboard Cite

Benzimidazole is a heterocyclic compound formed by fusing the benzene ring with an imidazole ring that contains two nitrogen atoms. Benzimidazole and its derivatives are prepared in different ways, including condensation of o-phenylenediamine with carbonyl compounds (aldehydes and ketones) or with carboxylic acids and their derivatives. The benzimidazoles can also be prepared by rearranging other heterocyclic compounds such as quinoxaline derivatives, triazole derivatives, etc. In recent decades, benzimidazoles were prepared using green methods such as microwaves, ultrasound, and the use of an environmentally friendly catalyst, as well as photochemical reactions. Benzimidazoles have attracted the interest of scientists and researchers due to the great medical efficacy shown by them for various diseases. The benzimidazole derivatives show many pharmacological activities such as anticancer, anti-inflammatory, antioxidant, anticoagulant, antiviral, etc. This review focuses on shedding light on benzimidazole and its derivatives, the most important methods used to prepare it, as well as the biological applications in our daily lives.

show abstract

“…Anti-Alzheimer's agents [192]- [194], Angiotensin II -AT1 Receptor Antagonist [195]- [200], Antiulcer activity [201]- [204], Anti-Tubercular activity [205]- [211],…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Biological Activity Of Benzimidazole Derivativesmentioning

confidence: 99%

“…In addition to the above medical applications, benzimidazole derivatives have been widely used as an essential part of biological applications including: antihypertensive activity, [154][155][156][157][158] antiprotozoal activity, [159][160][161][162][163] antiviral activity, [164][165][166][167] anthelmintic activity, [168][169][170][171][172] antidiabetic agents, [173][174][175][176][177] analgesic activity, 78,[178][179][180][181] antispasmodic activity, 182,183 antidepressant activity, [184][185][186][187][188][189] sphingosine kinase 1 inhibitor, 190,191 anti-Alzheimer's agents, [192][193][194] angiotensin II-AT1 receptor antagonists, [195][196][197][198]…”

Section: Other Biological Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Alheety,

Mohammed,

Farhan

et al. 2023

SynOpen

View full text Add to dashboard Cite

show abstract

“…Benzimidazole derivatives have become increasingly important in the past few years due to their diverse range of biological activities. These derivatives have been found to possess many beneficial properties, including anticancer, 19 anti-inflammatory, [20][21][22][23] analgesic, 24 antimicrobial, 25,26 antihelminthic, 27 antiprotozoal, 28 antiviral, 29,30 antifungal, 31 antioxidant, 32,33 antidiabetic, 34 antihistaminic, 35 antitubercular, 36 acetylcholinesterase inhibitor (anti-Alzheimer), 37,38 anti-HIV (Human Immunodefficiency Virus), 39 and anti-hypertensive properties. 40 They have shown promising results in the treatment of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, molecular docking and molecular dynamic studies of novel benzimidazole–thiazole derivatives as potent and selective COX-2 inhibitors

Irmak,

Saglık,

Celik

et al. 2023

New J. Chem.

View full text Add to dashboard Cite

show abstract

“…The benzimidazole scaffold represents a privileged structure because of its presence in inhibitory potential against AD. [ 15–23 ] When the literature is reviewed, it is seen that compounds containing the propargylamine group show inhibitory potential against MAO enzyme and these compounds are used as multifunctional agents against Alzheimer's disease. [ 24–27 ]…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO‐B dual inhibitors

Osmaniye

Evren

Sağlık

et al. 2021

Archiv der Pharmazie

View full text Add to dashboard Cite

To develop new acetylcholinesterase (AChE)–monoamine oxidase‐B (MAO‐B) dual inhibitors against Alzheimer's disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO‐B inhibitory activity, was used as the main structure. Moreover, like donepezil, it was thought that the enzyme AChE would provide π–π interactions with the peripheral anionic side in this structure. Piperazine derivatives were chosen for the cationic active site. The synthesis of the compounds was carried out in five steps. The structures of the compounds were determined using 1H‐NMR (nuclear magnetic resonance), 13C‐NMR, and high‐resolution mass spectrometry spectroscopic methods. First, the in vitro AChE, butyrylcholinesterase (BChE), MAO‐A, and MAO‐B inhibitory potentials of the obtained compounds were investigated. As a result of activity tests, compounds 5b, 5e, 5g, and 5h showed inhibitory activity against AChE; compounds 5e and 5g showed inhibitory activity against MAO‐B. None of the compounds showed inhibitory activity against BChE or MAO‐A. Compounds 5e and 5g showed dual inhibition. Among these compounds, compound 5g had inhibition potential similar to that of donepezil and selegiline. For compound 5g, further kinetic studies and Aβ‐plaque inhibitory potentials were investigated using in vitro methods. Molecular docking studies were performed using both AChE and hMAO‐B crystals to elucidate the compound's interactions with the enzyme active site. The binding modes of the compound on AChE were fully elucidated by molecular dynamics studies.

show abstract

New multitarget directed benzimidazole‐2‐thiol‐based heterocycles as prospective anti‐radical and anti‐Alzheimer's agents

Cited by 15 publications

References 15 publications

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Design, synthesis, molecular docking and molecular dynamic studies of novel benzimidazole–thiazole derivatives as potent and selective COX-2 inhibitors

Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO‐B dual inhibitors

Contact Info

Product

Resources

About