New Schiff bases of 2-(quinolin-8-yloxy)acetohydrazide and their Cu(ii), and Zn(ii) metal complexes: their in vitro antimicrobial potentials and in silico physicochemical and pharmacokinetics properties

Althobiti, Hanan A.; Zabin, Sami A.

doi:10.1515/chem-2020-0085

Cited by 26 publications

(12 citation statements)

References 34 publications

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“…These low values are an indication of nonelectrolytic nature of the complexes, implying that the anions in solution are within the coordination sphere. [ 41 ] Because the metal complexes are also large molecules, their migration is also limited in solution; hence, the molar conductivities deviate from those of ideal electrolytes. [ 41a ] Drug physicochemical parameters (e.g.…”

Section: Resultsmentioning

confidence: 99%

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Silver(I) complexes ofN,N′‐diarylformamidine ligands: Synthesis, crystal structures, and in vitro antibacterial studies

Bongoza

Zamisa

Munzeiwa

et al. 2022

Applied Organom Chemis

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Nine silver(I) N,N′‐diarylformamidine complexes of type [Ag (Ln)2X] (where X = NO3−, CF3COO−, and CF3SO3−, n = 1–5) were synthesised and characterised by physiochemical and spectroscopic techniques. Further confirmation for the formation of the complexes was provided by single‐crystal X‐ray crystallography. All complexes (but one) adopted linear geometry in which coordination was via two N atoms of two formamidine ligands with the anion (X) displaced from coordination sphere. In the structure of the exception, the anion is part of the coordination sphere and a T‐shaped geometry was adopted. The antimicrobial activity of the Ag(I) complexes were investigated against two Gram‐positive bacteria, that is, S. aureus ATCC 25923 and Methicillin‐resistant S. aureus ATCC 700699 (MRSA) and four Gram‐negative bacteria, that is, K. pneumoniae ATCC 31488, S. typhimurium ATCC 14026, P. aeruginosa ATCC 27853 and E. coli ATCC 25922 and they were evaluated based on ciprofloxacin and silver nitrate standards. The newly synthesised target complexes demonstrated promising antibacterial activity against Gram‐positive bacteria although less than the reference drug ciprofloxacin. The best active silver(I) complex contains a nitrate counter‐ion.

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Section: Resultsmentioning

confidence: 99%

“…[ 41 ] Because the metal complexes are also large molecules, their migration is also limited in solution; hence, the molar conductivities deviate from those of ideal electrolytes. [ 41a ] Drug physicochemical parameters (e.g. solubility, LogP o/w ) are vital in pharmacokinetics.…”

Section: Resultsmentioning

confidence: 99%

Silver(I) complexes ofN,N′‐diarylformamidine ligands: Synthesis, crystal structures, and in vitro antibacterial studies

Bongoza

Zamisa

Munzeiwa

et al. 2022

Applied Organom Chemis

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“…The spectra of the chromium complex observed two (428 nm, 608 nm) in Table 3, attributed to the allowed transfer 4 A 2 g → 4 T 1 g (F) and 4 A 2 g → 4 T 1 g (F) respectively [19]. It has been observed that the electron spectrum is complex cobalt(II) low spin octahedral (t 2 g 6 eg 1 ), one permissible transition 500 nm, which is 2 Eg 2 T 2 g (20).…”

Section: Electronic Spectra Magnetic Moments and Molar Conductance Of...mentioning

confidence: 99%

“…Heavy metal pollutions are released into the environment by industrial activities affecting the ecosystem. The metal content determination is necessary for controlling purposes because there is an active procedure for simultaneous enrichment and separation species from matrices of various analytical applications and separation procedures [4]. Cloud point extraction has become one of the most popular methods used to separate and enrich metal ions.…”

Section: ■ Introductionmentioning

confidence: 99%

Preparation and Characterization of New Tetra-Dentate N<sub>2</sub>O<sub>2</sub> Schiff Base with Some of Metal Ions Complexes

2021

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This study describes preparation a new series of tetra-dentate N2O2 dinuclear complexes Cr(III), Co(II)and Cu(II) of the Schiff base 2-[5-(2-hydroxy-phenyl)-1,3,4-thiadiazol-2-ylimino]-methyl-naphthalen-1-ol], (LH2) derived from 1-hydroxy-naphthalene-2-carbaldehyde with 2-amino-5-(2-hydroxy-phenyl)-1,3,4-thiadiazole. These ligands were characterized by FT-IR, UV-Vis, Mass spectra, elemental analysis, and 1H-NMR. All prepared complexes have been characterized by conductance measurement, magnetic susceptibility, electronic spectra, infrared spectrum, thermal Analysis (TGA), and metal analysis by atomic absorption. The stoichiometry of metal to ligand, magnetic susceptibility, and electronic spectra measurements show an octahedral geometry for all (Cr3+, Co2+, Cu2+) complexes. Conductivity measurement shows that the prepared (Co2+, Cu2+) complexes were nonelectrolyte except (Cr3+). Studying the extraction efficiency such as ligand concentration, temperature and incubation time, centrifuge time, amount of surfactant were evaluated and optimized. The linear range of ions Cr(III), Co(II) and Cu(II) with ligand (0.2–3, 0.2–4, 0.2–3, µg mL–1), each individually, and relative standard deviation (0.15%, 0.34%, 0.46%). The successful method was applied for the determination of trace metal ions in the wastewater.

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“…Molecules with 1,2,4-triazole moiety are very strong N-atom donors towards d-metal ions and can be readily deprotonated [7]. There is more focus on developing metal complexes as promising potential therapeutic agents because researchers believe that the coordination of organic molecules with metal ions enhances their biological activity [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Antimicrobial Activity and Docking Study of Vanadium Mixed Ligand Complexes Containing 4-Amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol and Aminophenol Derivatives

et al. 2021

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The synthesis of mixed-ligand complexes is considered an important strategy for developing new metal complexes of enhanced biological activity. This paper presents the synthesis, characterization, in vitro antimicrobial assessment, and theoretical molecular docking evaluation for synthesized oxidovanadium (V) complexes. The proposed structures of the synthesized compounds were proved using elemental and different spectroscopic analysis. The antimicrobial tests showed moderate activity of the compounds against the Gram-positive bacterial strains and the fungal yeast, whereas no activity was observed against the Gram-negative bacterial strains. The performance of density functional theory (DFT) was conducted to study the interaction mode of the targeted compounds with the biological system. Calculating the quantitative structure-activity relationship (QSPR) was performed depending on optimization geometries, frontier molecular orbitals (FMOs), and chemical reactivities for synthesized compounds. The molecular electrostatic potentials (MEPs) that were plotted link the interaction manner of synthesized compounds with the receptor. The molecular docking evaluation revealed that the examined compounds may possess potential antibacterial activity.

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New Schiff bases of 2-(quinolin-8-yloxy)acetohydrazide and their Cu(ii), and Zn(ii) metal complexes: their in vitro antimicrobial potentials and in silico physicochemical and pharmacokinetics properties

Cited by 26 publications

References 34 publications

Silver(I) complexes ofN,N′‐diarylformamidine ligands: Synthesis, crystal structures, and in vitro antibacterial studies

Silver(I) complexes ofN,N′‐diarylformamidine ligands: Synthesis, crystal structures, and in vitro antibacterial studies

Preparation and Characterization of New Tetra-Dentate N<sub>2</sub>O<sub>2</sub> Schiff Base with Some of Metal Ions Complexes

Preparation, Antimicrobial Activity and Docking Study of Vanadium Mixed Ligand Complexes Containing 4-Amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol and Aminophenol Derivatives

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