New scents using eco-friendly solvents: Oxo synthesis of aldehydes from caryophyllane sesquiterpenes

Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress

“…In the past decade, Gusevskaya and coworkers developed a series of catalytic transformations of renewable alkenes to gain access to new fragrant molecules [ 30 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 ]. For example, they subjected myrtenol and nopol to the synthesis of polycyclic fragrances via hydroformylation and the subsequent intramolecular acetalization [ 131 ].…”

“…For example, they subjected myrtenol and nopol to the synthesis of polycyclic fragrances via hydroformylation and the subsequent intramolecular acetalization [ 131 ]. In 2020, they reported a hydroformylation protocol in eco-benign solvents to produce new woody fragrances from natural caryophyllane sesquiterpenes [ 132 ]. Previously, they discovered a unique bridged O -heterocycle with a sweet, woody odor by the heteropoly acid-catalyzed cascade coupling/cyclization of limonene and crotonaldehyde [ 133 ] ( Scheme 12 b).…”