New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin‐3‐Carboxylic Acid as Antiproliferative Agents

Abstract

New complexes of samarium(III), gadolinium(III), and dysprosium(III) with coumarin-3-carboxylic acid (HCCA) were prepared by the reaction of the ligand with respective metal nitrates in ethanol. The structures of the final complexes were determined by means of physicochemical data, elemental analysis, IR and Raman spectra. The metal-ligand binding mode in the new Ln(III) complexes of coumarin-3-carboxylic acid was elucidated. The vibrational study gave evidence for bidentate coordination of CCA− to Ln(III) ions through the carbonylic oxygen and the carboxylic oxygen atoms. The complexes were tested for antiproliferative activitiy on the chronic myeloid leukemia-derived K-562, overexpressing the BCR-ABL fusion protein. Cytotoxicity towards tumor cells was determined for a broad concentration range. The samarium salt exerted a very weak antiproliferative effect on these cells. This is in contrast to the lanthanide complexes, especially samarium complex, which exhibited potent antiproliferative activity. The present study confirms our previous observations that the lanthanide complexes of coumarins exhibit antiproliferative activity towards K-562 cell line.

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

“…Interestingly, the m C@O (lactone) stretching vibration was shifted in all of the complexes by 11-56 cm À1 relative to the free ligand, upon formation of the Ag(I) complexes as was observed in the coumarin-3-carboxylates. Several reports have attributed such a shift to the participation of the coumarin lactone carbonyl in complexation to the metal ion [37][38][39] but it has also been reported for other coumarin derivatives where the lactone was not involved in complexation [40,41]. In the latter instance the shift may be attributed to an increase in polarity of the lactone ring which can occur upon metal complexation.…”

Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines☆

“…Additionally, evidence is rising that many REE exhibit anti-cancerogenic properties [24][25][26][27] . Therefore, magnesium alloys containing REE could be of particular interest for bone cancer treatments.…”

Corrosion protection afforded by praseodymium conversion film on Mg alloy AZNd in simulated biological fluid studied by scanning electrochemical microscopy

“…In biomedical application, use of RE compounds should also be considered from the perspective of their potential cytotoxicity. Anti-carcinogenic properties of REs has been shown in number of studies [18][19][20][21], however some studies have also reported cytotoxic and hepatotoxic effects at high dose [22][23][24][25]. It has been shown that rare-earth alloying elements including Ce, Nd, Y, and Yb have no adverse effect on growth of living cells but they can induce inflammatory effects at high concentration [26].…”