New Roles for Tubulin in Membrane Function

Berlin, Richard D.; Caron, Joan M.; Huntley, Raphael; Melmed, RN; Oliver, Janet M.

doi:10.1016/b978-0-12-615080-3.50043-4

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…MAP-2, in particular, can cross-link MT with CV (49) and is also capable of binding to actin and inducing the formation of actin filament bundles (48). It is known that tubulin binds to, and may at least partially insert in, phospholipid vesicles (5,8,19,40). Indeed, tubulin binds preferentially in vitro to rat hepatic membrane fractions that are involved in protein, membrane, and organelle translocation (40).…”

Section: Discussionmentioning

confidence: 99%

Tubulin as a molecular component of coated vesicles.

Kelly¹,

Passaniti²,

Woods³

et al. 1983

The Journal of Cell Biology

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Two proteins of 53,000 and 56,000 mol wt have been found to be associated with coated vesicles (CV) purified from bovine brain and chicken liver. These proteins share molecular weights, isoelectric points, and antigenic determinants with a-and ~-tubulins purified from bovine brain. Based on SDS PAGE and electron microscopic analysis of controlled pore glass bead exclusion column fractions, both the tubulins and the major CV polypeptide clathrin were found to chromatograph as components of a single kinetic particle. In addition, tubulin and CV antigens assayed by a sensitive enzyme-linked-immunoadsorbent method eluted from the columns with constant stoichiometry. These data provide evidence that tubulin is a molecular component of coated vesicles.

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Section: Discussionmentioning

confidence: 99%

Tubulin as a molecular component of coated vesicles.

Kelly¹,

Passaniti²,

Woods³

et al. 1983

The Journal of Cell Biology

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“…Activities of the ATP-dependent proton pumps, the Na + /H + antiporters and the anion antiporters in virus-infected cells may provide some clues to this process. For instance, amiloride, a well established inhibitor of Na + /H + ATP-ase, and colchicine (an antitubulin), a recently recognized activator of this enzyme (31), may be involved in the regulation of intracellular pH, via the membrane-bound tubulin (31).…”

Section: Inhibition Of Viral Internalization: Role Of Transglutaminasmentioning

confidence: 99%

RME-based pharmacology: The inhibition of viral entry as therapeutic perspective in viral diseases including AIDS. Hypothesis updated and enlarged

Chaldakov

Yanev

2018

Biomedical Reviews

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and Laboratory of Drug coated pits/vesicles was the best-characterized endocytic pathway. Since then now, intensive research on the mechanisms of both RME and receptor-mediated virus-cell fusion (receptor-mediated fusion-RMF) helped to expand the list of chemical compounds with potential clinical application as antiviral agents, the so-called entry inhibitors, e.g. (i) inhibitors of clathrin-, dynamin-2-, caveolin-and/or lipid rafts-dependent RME, and (ii) inhibitors of RMF. Accordingly, in the present Dance Round we update and enlarge our hypothesis of RME-based antiviral pharmacology.

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General Physiology of Tubulins and Microtubules

Dustin

1984

Microtubules

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New Roles for Tubulin in Membrane Function

Cited by 7 publications

References 15 publications

Tubulin as a molecular component of coated vesicles.

Tubulin as a molecular component of coated vesicles.

RME-based pharmacology: The inhibition of viral entry as therapeutic perspective in viral diseases including AIDS. Hypothesis updated and enlarged

General Physiology of Tubulins and Microtubules

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