“…The vast majority of patients have an indolent and protracted clinical course, lasting for years to decades, with persistent disease and/or occasional relapses (chronic relapsing clinical course) [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 26 ]; most iTLPD-GIs have limited or no response to conventional chemotherapy [ 3 , 6 , 7 , 10 , 11 , 12 , 14 , 15 , 16 , 24 , 25 ], and it has been suggested that localized forms may benefit from involved-field radiotherapy (IFRT) [ 27 ].…”