New Resin Acid Derivatives: Diisocyanate, Diurethanes and Diureides

Gigante, Bárbara; Esteves, M. Alexandra; Curto, Manuel; Ascenso, João; Prabhakar, Sundaresan; Lobo, Ana M.

doi:10.1080/00397919808005936

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Catalytic reduction of Ar-NO 2 into Ar-NH 2 has been studied very well and reviewed, 9 13 excess Zn, HCOONH 4 / MeOH, 14 H 2 , Pd/C (cat. )/EtOH, 15 5 atm H 2 , Pd/C (cat.) in EtOH; 16 HCOOH-Pd/C, 17 SnCl 2 in HCl/EtOH 18 etc.…”

Section: Resultsmentioning

confidence: 99%

“…Simultaneously converting of m -Ar(NO 2 ) 2 into m -Ar(NH 2 ) 2 with >90% yield has also been reported in the presence of a catalyst, such as Rh 6 (CO) 16 in THF/NEt 3 /H 2 O, Ti(SO 4 ) 2 (2.4 wt %) and H 2 SO 4 (35%)/H 2 O; NaBH 4 , FeCl 2 , H 2 , trans -PdPy 2 Cl 2 in EtOH; excess Zn, HCOONH 4 /MeOH, H 2 , Pd/C (cat. )/EtOH, 5 atm H 2 , Pd/C (cat.) in EtOH; HCOOH−Pd/C, SnCl 2 in HCl/EtOH etc.…”

Section: Resultsmentioning

confidence: 99%

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Parallel Approach for Solution-Phase Synthesis of 2-Quinoxalinol Analogues and Their Inhibition of LPS-Induced TNF-α Release on Mouse Macrophages in Vitro

et al. 2004

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A parallel solution-phase synthesis of 2-quinoxalinol analogues is described. The key step-simultaneous reductions of m-Ar(NO2)2 to m-Ar(NH2)2 was investigated extensively. We obtained preliminary pharmacological activity of those analogues for the inhibition of LPS-induced TNF-alpha release on mouse macrophage in vitro. Two compounds revealed inhibitory activity, with IC50 values of 0.40 microM (7-amino-6-[(3-methoxypropyl)amino]-3-methyl-2-quinoxalinol) and 2.2 microM (7-amino-6-[(3-butoxypropyl)amino]-3-methyl-2-quinoxalinol), respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Parallel Approach for Solution-Phase Synthesis of 2-Quinoxalinol Analogues and Their Inhibition of LPS-Induced TNF-α Release on Mouse Macrophages in Vitro

et al. 2004

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ChemInform Abstract: New Resin Acid Derivatives: Diisocyanates, Diurethanes and Diureides.

et al. 1998

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Scaffold-directed and traceless synthesis of tricyclic quinoxalinone imidazoles under microwave irradiation

Thummanagoti

Chen

et al. 2010

Mol Divers

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Traceless synthesis of 2-aminoimidazoquinoxalinones has been performed on soluble polymer support under open-vessel microwave dielectric heating. The reaction progression is monitored directly by the conventional proton NMR which indicated no release of the substrate from the support. Fmoc-deprotected amino acid polymer conjugates react with 1,5-difluoro-2,4-dinitro benzene to yield polymer bound dinitro fluoro amines, which are further substituted by various primary amines to yield PEG-immobilized dinitrodiamines. Simultaneous reduction of aromatic meta-dinitro group leads to the traceless release of 2-quinoxalinones, followed by N-hetero cyclization with various isothiocyanates in the presence of mercury(II)chloride to furnish 2-aminoimidazoquinolinone rings with three points of diversity at rapid pace.

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New Resin Acid Derivatives: Diisocyanate, Diurethanes and Diureides

Cited by 6 publications

References 14 publications

Parallel Approach for Solution-Phase Synthesis of 2-Quinoxalinol Analogues and Their Inhibition of LPS-Induced TNF-α Release on Mouse Macrophages in Vitro

Parallel Approach for Solution-Phase Synthesis of 2-Quinoxalinol Analogues and Their Inhibition of LPS-Induced TNF-α Release on Mouse Macrophages in Vitro

ChemInform Abstract: New Resin Acid Derivatives: Diisocyanates, Diurethanes and Diureides.

Scaffold-directed and traceless synthesis of tricyclic quinoxalinone imidazoles under microwave irradiation

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