New Resilience Instrument for Family Caregivers in Cancer: A Multidimensional Item Response Theory Analysis

Liang, Mu Zi; Tang, Ying; Chen, Peng; Liang, Jian; Sun, Zhe; HU, GUANG YUN; Yu, Yuan Liang; Ye, Zeng Jie

doi:10.21203/rs.3.rs-924762/v1

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…The challenge with this approach is that there is no information on the percentage of variances an item contributes to the general trait (i.e., general emotions). Thus, there has been less attention paid to instances where a particular item can provide information for the general emotion construct as well as information to a sub-domain, which a bifactor multidimensional item response theory (MIRT) would help provide such information ( Reckase, 2009 ; Liang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Examining the underlying latent structure of the sports emotion questionnaire: Insights from the bifactor multidimensional item response theory

et al. 2022

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BackgroundDespite the widespread use of the sports emotion questionnaire (SEQ) in several studies, it is surprising that only a few have explicitly tested the validity and utility of the instrument in non-western populations. Besides, the issue of dimensionality and the latent structure of the instrument remain inconclusive given that several authors have revealed different factor structures across diverse populations. The central concern is whether the items on the various dimensions, proposed for the original SEQ, offer adequate information to their respective expected subscale or otherwise. This study assessed the underlying latent structure of the SEQ using confirmatory and bifactor multidimensional item response (MIRT) models.MethodsThrough a well-designed validation study 300 athletes from three West African countries, participating in the 2018 West African University Games were surveyed to respond to the SEQ. The data were analyzed using first, a 5-factor confirmatory factor analysis (CFA) via the MIRT model and second, a bifactor MIRT analysis.ResultsThe results revealed that items on the SEQ were fairly good in measuring the construct under the respective domains of the instrument. However, the outcome of the bifactor model showed that the majority of the items on the SEQ explained common variance in relation to the general factor other than the specific domains (5-dimensions).ConclusionFindings of the bifactor model question whether the sub-dimensions of the SEQ are needed since most of the items on the SEQ explained larger variances in the general factor than any of the five domains. It is concluded that instruments like SEQ should be scored for a general factor and not as sub-dimensions. Further investigations are encouraged by scholars within the area to probe the dimensionality of the SEQ.

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Section: Introductionmentioning

confidence: 99%

Examining the underlying latent structure of the sports emotion questionnaire: Insights from the bifactor multidimensional item response theory

et al. 2022

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“…Schwann cells suffered oxidative stress, mitochondrial malfunction, and death as a result of being exposed to high levels of glucose. Still, these effects were reversed by activating the SIRT3/PGC-1α/SOD2 pathway when co-treatment with formononetin [33]. There are some shreds of evidence to show that SIRT3 is implicated in the etiology of DR. SIRT3 absence led to an excessive generation of ROS in the mitochondria, resulting in impaired function of retinal pigment epithelial cells due to elevated glucose levels and platelet-derived growth factors [34].…”

Section: Discussionmentioning

confidence: 99%

MiR-29a-5p engages in the mechanism of diabetic retinopathy by specifically targeting SIRT3

He,

Wei,

Liang

et al. 2024

Preprint

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Whether miR-29a-5p is associated with diabetic retinopathy (DR) is still a subject of ongoing discussion. The current research examines the involvement of miR-29a-5p in regulating apoptosis, oxidative stress, and inflammation of retinal ganglion cells (RGCs) generated by high glucose (HG). Additionally, we are interested in analyzing the contribution of miR-29a-5p in developing DR. We obtained peripheral blood samples from 7 people with DR and 14 individuals without DR. Subsequently, we conducted biochemical indices analyses and qRT-PCR. We randomly divided RGCs into low glucose groups, HG groups, HG + inhibitor negative control groups, and HG + miR-29a-5p inhibitor groups. SIRT3 siRNA was transfected into RGCs through lipofectamine 3000 reagent. Cell vitality was detected by MTT; qRT-PCR was applied to identify miR-29a-5p expression; Detection of ROS, SOD, and MDA levels was quantified using the DCFH-DA, WST-1, and colorimetric methods, respectively; IL-6 and TNF-α contents were analyzed utilizing ELISA; Dual-luciferase gene reporter experiment was used to examine if SIRT3 is the specific target gene of miR-29a-5p; Flow cytometry evaluated apoptosis in RGCs; The technique of Western blotting identified the expression of Caspase-3, Bax and Bcl-2 proteins. The expression of miR-29a-5p was markedly elevated in individuals with DR, and it had positive correlations with levels of total cholesterol (TC) and fasting blood glucose (FBG). The combination of miR-29a-5p, total cholesterol, and triglycerides (TG) exhibits significant diagnostic value for DR, demonstrating both high sensitivity and specificity. High glucose stimulated the expression of miR-29a-5p in RGCs and worsened cellular oxidative stress, inflammatory response, and apoptotic levels. Transfection of miR-29a-5p inhibitor protected RGCs against HG-induced oxidative injury, inflammation, and apoptosis. Furthermore, the dual-luciferase reporter experiment provided confirmation that SIRT3 was a target gene of miR-29a-5p, as it negatively regulated SIRT3 expression. Notably, SIRT3 knockdown abolished the protection of miR-29a-5p inhibition on RGCs. Suppression of the miR-29a-5p gene safeguards RGCs against injury caused by high glucose via boosting SIRT3 signaling, which might provide a new prevention and treatment strategy for DR.

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“…The graded response model of the ordered polytomous item response theory family was used for the validation study ( Samejima, 1969 , 1997 ). The study focused on between-item multidimensional structure ( Ye et al, 2019 ; Liang et al, 2021 ). The IRT PRO software (version 4.2) was used for the analysis ( Cai et al, 2011b ).…”

Section: Methodsmentioning

confidence: 99%

Re-assessing the Psychometric Properties of Stress Appraisal Measure in Ghana Using Multidimensional Graded Response Model

et al. 2022

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Despite the widespread use of the stress appraisal measure questionnaire in sport psychology literature, information on the psychometric properties of this survey instrument across different cultures and samples is still lacking. This study sought to validate the stress appraisal measure among male football players in the Ghana’s Premier League using the multidimensional item response theory. The descriptive cross-sectional survey design was adopted to recruit 424 footballers from the 2020/2021 Ghana Premier League season using the census approach. The 28-item Stress Appraisal Measure was used to assess six (6) appraisal mechanisms under primary and secondary cognitive appraisals. The ordered polytomous item response theory was used for analyzing the data. The study found that although some items were problematic, the majority of them were found to have good item parameters, effective scale option functioning, and provided adequate empirical information in the measurement of stress appraisal. This research concluded that the stress appraisal measure has promising applicability among male footballers who participated in the premier league in Ghana. Future researchers are encouraged to re-validate the stress appraisal measure with a different sample to contribute to the understanding of the applicability of the instrument in non-western populations.

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New Resilience Instrument for Family Caregivers in Cancer: A Multidimensional Item Response Theory Analysis

Cited by 4 publications

References 21 publications

Examining the underlying latent structure of the sports emotion questionnaire: Insights from the bifactor multidimensional item response theory

Examining the underlying latent structure of the sports emotion questionnaire: Insights from the bifactor multidimensional item response theory

MiR-29a-5p engages in the mechanism of diabetic retinopathy by specifically targeting SIRT3

Re-assessing the Psychometric Properties of Stress Appraisal Measure in Ghana Using Multidimensional Graded Response Model

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