New research on development of solid lipid nanoparticles

Huo, Jun; Zhou, Shiwen

doi:10.1016/s1000-1948(08)60023-4

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…By employing glyceryl monostearate (GMS) as the lipid phase and poloxamer P123 (E 20 PO 70 EO 20 ) as the aqueous phase, SLNs were fabricated by using microemulsification methodology . Further, with the objective of enhancing the stability of microemulsion droplets for formulating stable SLNs, the Cu‐CPC metal amphiphilic complex as an efficient micellar agent and a source of copper ions were incorporated into the system to assist the additional co‐micellization step.…”

Section: Methodsmentioning

confidence: 99%

Designed Meso‐macroporous Silica Framework Impregnated with Copper Oxide Nanoparticles for Enhanced Catalytic Performance

2018

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The template efficacy of solid lipid nanoparticles for generating porous silica materials with the amalgamation of Cu‐functionalized cetylpyridinium chloride (CPC; as a co‐emulsifier and as a metal source for generation of CuO oxide nanoparticles) has been explored. Impregnation of CuO nanoparticles (∼10–12 nm) onto the silica matrix proffers to be a propitious route for the fabrication of twin sized porous, highly active catalytic materials. The surface morphology and structural characterization of the synthesized CuO@meso‐macroporous silica framework was elucidated by TEM, field ‐emission (FE)‐SEM, energy‐dispersive X‐ray (EDX), wavelength dispersive (WD)‐XRF, X‐ray photoelectron spectroscopy (XPS), small‐angle X‐ray scattering (SAXS), XRD, and N2 adsorption/desorption studies. All the results have shown that there exists a structural network interconnecting the mesopores with macropores. The catalytic performance of the synthesized framework (ascribed catalyst) was checked for two model reactions. For the reduction of p‐nitrophenol to p‐aminophenol, only 0.25 % (w/v) catalyst was sufficient to accomplish the reaction in 6 min, giving 99.9 % yield. On the other hand, the redox reaction of potassium hexacyanoferrate(III) and sodium thiosulfate utilized 5 % (w/v) catalyst and completed the reaction in 40 min, yielding 98.43 %. Therefore, CuO@meso‐macroporous silica materials could hold great importance in the world of nanocatalysis owing to the present promising results.

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Section: Methodsmentioning

confidence: 99%

Designed Meso‐macroporous Silica Framework Impregnated with Copper Oxide Nanoparticles for Enhanced Catalytic Performance

2018

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“…Syntheses of dendrimers include the use of Tomalia's divergent growth approach, convergent growth approach, and orthogonal coupling strategy 26,66,67 , while solid lipid nanoparticles are prepared by high shear homogenization, ultrasound dispersion technique, high pressure homogenization, solvent emulsification/evaporation, microemulsion and solvent diffusion 33,68,69 .…”

Section: Methods Of Fabricationmentioning

confidence: 99%

Nanotechnology and Drug Delivery Part 2: Nanostructures for Drug Delivery

Ochekpe¹,

Olorunfemi²,

Ngwuluka³

2009

Trop. J. Pharm Res

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“…Other advantage is the small dimensions of these NPs permit the protection of the drug and facilitate administration by parenteral route (e.g. intravenous) and oral route, however the contact with gastrointestinal fluids has been a critical problem due to the particle size which maximizes the surface area for enzymatic degradation, for example, and it has an impact for drug stability [64,77].…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Highlights in nanocarriers for the treatment against cervical cancer

Medina-Alarcón

Voltan

Fonseca-Santos

et al. 2017

Materials Science and Engineering: C

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Cervical cancer is the second most common malignant tumor in women worldwide and has a high mortality rate, especially when it is associated with human papillomavirus (HPV). In US, an estimated 12,820 cases of invasive cervical cancer and an estimated 4210 deaths from this cancer will occur in 2017. With rare and very aggressive conventional treatments, one sees in the real need of new alternatives of therapy as the delivery of chemotherapeutic agents by nanocarriers using nanotechnology. This review covers different drug delivery systems applied in the treatment of cervical cancer, such as solid lipid nanoparticles (SNLs), liposomes, nanoemulsions and polymeric nanoparticles (PNPs). The main advantages of drug delivery thus improving pharmacological activity, improving solubility, bioavailability to bioavailability reducing toxicity in the target tissue by targeting of ligands, thus facilitating new innovative therapeutic technologies in a too much needed area. Among the main disadvantage is the still high cost of production of these nanocarriers. Therefore, the aim this paper is review the nanotechnology based drug delivery systems in the treatment of cervical cancer.

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New research on development of solid lipid nanoparticles

Cited by 9 publications

References 14 publications

Designed Meso‐macroporous Silica Framework Impregnated with Copper Oxide Nanoparticles for Enhanced Catalytic Performance

Designed Meso‐macroporous Silica Framework Impregnated with Copper Oxide Nanoparticles for Enhanced Catalytic Performance

Nanotechnology and Drug Delivery Part 2: Nanostructures for Drug Delivery

Highlights in nanocarriers for the treatment against cervical cancer

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