New regulations for accessing plant biodiversity samples, what is ABS?

Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discovery

“…Such efforts must also be made in good agreement with newly enforced ABS legislation. 3 To achieve such goals, developments are still needed in various elds. Key to the whole process is the design of CNE libraries and this may vary according to nal objectives.…”

“…1 This is mainly attributable to the lengthy and tedious procedures involved in the isolation and characterisation of bioactive NPs, to the redundancy of NPs stored within libraries sourced for discovery, and to the limited compatibility of crude natural extracts (CNEs) with the high throughput of bioactivity screening campaigns on selected targets. 2 To address these issues, the scientic community has revitalised the discipline by: (I) rationally exploiting collections of CNEs and NPs representative of terrestrial and marine biodiversity while taking into account regulations for a fair and equitable sharing of benets arising from the usage of genetic resources (Nagoya Protocol) 3 and (II) developing advanced analytical protocols for the rapid identication of previously known NPs in CNEs (dereplication) to avoid their unnecessary re-isolation. For this latter aspect, the metabolite proling of complex CNEs for the early identication of NPs (metabolite annotation) has evolved considerably over the last decade in line with the development of metabolomics in other elds of life sciences.…”

Discovery of anti-infective compounds againstMycobacterium marinumafter biotransformation of simple natural stilbene scaffolds by a fungal secretome

“…Recent advances in “omics” techniques, computational methods, and innovative screening models have revitalized the field of phenotypic screens in complex systems, and opened up new avenues of exploration (Rossiter et al, 2017; Wolfender et al, 2019). Despite this advance, several challenges in NP drug discovery remain, such as access to novel biological material, intraspecies variability and supply (David, 2018; Kingston, 2011). An alternative approach that takes advantage of the aforementioned advance is the generation of new NP-like compounds based on NP scaffolds.…”

Essential Oils Land Footprint: A Sustainability Meta-Analysis of Essential Oils Biopesticides

“…These promising perspectives for the application of EOs for the sustainable transformation of both economy and society are not unquestioned. The relative discussions, initially focused on legislative and regulatory issues, soon were expanded towards intellectual property rights [13], economic feasibility [14] and ecological sustainability [15]. In specific, Hall and Bawa [16] in their study concerning the trade-offs between economic and ecological issues have indicated their unfavourable impacts on nature conservation caused by the harvesting of wild plant populations.…”