New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet‐rich plasma in five patients: Our Experience

Friji, M T; Gopalakrishnan, S.; Sc, Verma; Parida, Pradipta-Kumar; Mohapatra, Devi Prasad

doi:10.1111/coa.12269

Cited by 16 publications

(16 citation statements)

References 10 publications

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“…They attributed this to the stimulatory effect of mesenchymal stem cells within the fat graft, yet they could not proof or deny other nonmesenchymal mechanism for their results. The main drawbacks of Friji et al study are the small number of cases and that the results are not substantiated by histopathological examination [19].…”

Section: Discussionmentioning

confidence: 87%

“…Sino-Nasal Outcome Test-20 scores had improved from an average of 36 to an average of 8. In addition, the nasal mucociliary clearance time was significantly shorter after 960 s than before 1995 s intervention [19]. They attributed this to the stimulatory effect of mesenchymal stem cells within the fat graft, yet they could not proof or deny other nonmesenchymal mechanism for their results.…”

Section: Discussionmentioning

confidence: 95%

“…Since no treatment modality whether alone or combined provided long-lasting cure of 1ry AR as no one addressed the reversal of basic pathologic alteration in the microanatomy [19], we were derived to challenge the value of platelet-rich plasma as a biogenic stimulator for healing acceleration aiming to suggest a new treatment modality that might reverse the atrophic changes of nasal mucosa in primary atrophic rhinitis.…”

Section: Introductionmentioning

confidence: 99%

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Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis

Mostafa

Ayad

2020

Egypt J Otolaryngol

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Background Primary atrophic rhinitis (1ry AR) is a chronic nasal disease characterized by the loss of mucociliary clearance and presence of viscid secretions and dried crusts that causes a characteristic foul odor, usually bilateral. A large range of treatment modalities had been tried, yet there is still no agreement upon a curative treatment with long-lasting success. The purpose of the study was to assess the value of platelet-rich plasma as a biogenic stimulator for healing acceleration in primary atrophic rhinitis. A total of 78 cases clinically diagnosed to have primary atrophic rhinitis were included. Nasal endoscopy, Sino-Nasal Outcome Test-25 questionnaire, mucociliary clearance assessment by saccharine transit time test, and biopsy specimens were achieved before 1 month and 6 months after the application of platelet-rich plasma in group A (cases) and platelet-poor plasma in group B (controls). Results All patients in group A showed endoscopic improvement and reduction in the incidence of the most frequently encountered symptoms before platelet-rich plasma injection including nasal crusts, 36 (92.30%); foetor, 31 (79.48%); nasal obstruction, 30 (76.92%); anosmia, 17 (43.58%); and epistaxis, 7 (17.94%) to nasal crusts, 9 (23.07%); foetor, 13 (33.33%); nasal obstruction, 14 (35.89%); anosmia, 13 (33.33%); and epistaxis, 3 (7.69%), 6 months after, and this was reflected in the reduction of the Sino-Nasal Outcome Test-25 scores which was averaged 40 before platelet-rich plasma to 9, 6 months after. Similarly, the mucociliary clearance time was significantly reduced after platelet-rich plasma injection; saccharine transit time test was initially averaged at 1980 s and got reduced to 920 s, 6 months after platelet-rich plasma injection. Conclusion The use of platelet-rich plasma as a biogenic stimulator is a possible innovative less invasive approach that can be effective in repairing tissue dystrophy through further future studies.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis

Mostafa

Ayad

2020

Egypt J Otolaryngol

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“…The benefits of this treatment include easy access, minor tissue damage after transplantation, rapid proliferation, and wide range of source. However, only few previous reports have described the use of stem cells for the treatment of ENS [ 23 , 24 ]. A previous study reported the effect of ADSC on the nasal mucosa and the underlying mechanism in the treatment of ENS [ 23 ]; the authors used fat particles combined with ADSC in 30 patients with ENS.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Autologous Stromal Vascular Fraction in the Treatment of Empty Nose Syndrome

Kim

Hong

Choi³

et al. 2018

Clin Exp Otorhinolaryngol

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Objectives Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS.Methods In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF. Data, including demographic data, pre- and postoperative Sino-Nasal Outcome Test-25 (SNOT-25) scores, overall patient satisfaction, and postoperative complications, were prospectively collected. Nasal secretion was assessed using the polyurethane foam absorption method, and the levels of biological markers were analyzed in both ENS group and control group using enzyme-linked immunosorbent assay. The SVF extracted from abdominal fat was diluted and injected into both inferior turbinates.Results Among the 10 initial patients, one was excluded from the study. Subjective satisfaction was rated as “much improved” in two and “no change” in seven. Among the improved patients, the mean preinjection SNOT-25 score was 55.0 and the score at 6 months after injection was 19.5. However, the average SNOT-25 score of nine participants at 6 months after injection (mean±standard deviation, 62.4±35.8) did not differ significantly from the baseline SNOT25 score (70.1±24.7, P>0.05, respectively). Among the various inflammatory markers assessed, the levels of interleukin (IL)-1β, IL-8, and calcitonin gene-related peptide were significantly higher in ENS patients. Compared with preinjection secretion level, the nasal secretions from SVF-treated patients showed decreased expressions of IL-1β and IL-8 after injection.Conclusion Although SVF treatment appears to decrease the inflammatory cytokine levels in the nasal mucosa, a single SVF injection was not effective in terms of symptom improvement and patient satisfaction. Further trials are needed to identify a more practical and useful regenerative treatment modality for patients with ENS.

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“…Staging surgery is often used to prevent these problems. For patients with secondary atrophic rhinitis with nasal septum perforation, the cavity-narrowing operation and nasoseptal perforation repair operation are two common choices [4]. However, the optimal sequence for these operations is not clear.…”

Section: Introductionmentioning

confidence: 99%

Computational Fluid Dynamics (CFD) Investigation of Aerodynamic Characters inside Nasal Cavity towards Surgical Treatments for Secondary Atrophic Rhinitis

Zhou

Lou

et al. 2019

Mathematical Problems in Engineering

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Purpose. To use computational fluid dynamics (CFD) technology to fundamentally understand (1) the effect of surgical treatments on nasal physiology for secondary atrophic rhinitis and (2) the priority of operations. Subjects and Methods: With the aid of medical imaging and CFD modeling, three virtual operations (nasoseptal perforation repair, cavity narrowing, and a combination of both) were performed to analyze airflow, nasal resistance, and wall shear stress. Results. Compared with the cavity-narrowing virtual operation, nasal resistance was not significantly altered by septal perforation repair virtual operation. Airflow allocation changed with more air flowing through the olfactory area and less though the nasal floor after all operations, especially the cavity-narrowing operation. Wall shear stress at the original epistaxis area and the nasal floor was reduced after the cavity-narrowing operation. Conclusions. Simulation results suggest that the cavity-narrowing operation takes priority over septal perforation repair if a staged surgery approach is adopted. If only one operation can be chosen, the cavity-narrowing operation is better than the septal perforation repair. This work shows that CFD-based modeling may aid precision medicine.

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New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet‐rich plasma in five patients: Our Experience

Cited by 16 publications

References 10 publications

Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis

Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis

Efficacy and Safety of Autologous Stromal Vascular Fraction in the Treatment of Empty Nose Syndrome

Computational Fluid Dynamics (CFD) Investigation of Aerodynamic Characters inside Nasal Cavity towards Surgical Treatments for Secondary Atrophic Rhinitis

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