“…During our ongoing research focused on the stereoinductive properties of C 2 -symmetric diaminobithiophenes (DAT2, 1 , Figure ) 6 in metallo-catalyzed transformations, we demonstrated that the combination of 1 with Cu(OAc) 2 8 (0.1−5 mol %) smoothly promoted the condensation of nitromethane with a variety of aldehydes in excellent enantiomeric excess . The ready synthetic accessibility and facile manipulation of thiophene-based compounds allowed us to prepare in few steps a C 1 -symmetric DAT2 analogue tethered to poly(ethylene glycol) (MeO-PEG 5000 , 2 , Figure )that was effectively employed in Pd-catalyzed asymmetric allylic alkylations. Here, the recovery of the supported ligand for several runs without any loss of activity was demonstrated.…”