Authors' Contribution RL and LG conceived and designed the study. RL, LG, JF, YH, ZS and SZ contributed to the preparation of the manuscript. LG, KL, LL, RL performed the trial. JF, YH, ZS prepared Figures 1-4. KL, LL, JF, YH and SZ prepared Tables and Figures S1-S3. All authors also read and approved the manuscript.