New recording genes and genetic mutations of H. pylori genome in gastroduodenal disease patients in Basrah province-Iraq

Abstract

The aim of this study was to investigate the molecular finding of the most important H. pylori virulence factors cagA, vacA genotypes in gastric biopsies of patients with gastroduodenal diseases infected with Helicobacter pylori in Basrah-Iraq by using conventional PCR and sequencing technologies, to give acknowledge about the immunopathogenesis of the studied virulence factors in patients with gastroduodenal disorder. A case-control study included 112 confirmed gastroduodenal patients and 112 healthy individuals as a control group. Data about age, gender, smoking, alcohol abuse, family history, occupation, residence, and clinical findings for all study populations were collected. The study show a significant effect of these virulence factors with an increased risk of gastroduodenal disorder.