New reagents for the intermolecular and intramolecular pinacolic coupling of ketones and aldehydes

Mechanistic Study of Half-titanocene-based Reductive Pinacol Coupling Reaction

“…CpTiCl 3 has catalytic activities on the asymmetrical and intramolecular coupling reactions of ketones and aldehydes. 31 In order to confirm the catalytic activity of half-titanocene-based systems for intermolecular coupling, we tested the catalytic behaviors for the intermolecular coupling reaction employing CpTiCl 3 with amalgamated magnesium as described in previous studies (see the experimental section for details). In addition to having activity for intramolecular coupling reactions as previously reported, the CpTiCl 3 -Mg (Hg) system showed catalytic activity for intermolecular homo-coupling reactions with a high yield and moderate diastereoselectivity (Table 1).…”

The complex packing pattern ofcis-1,2-dimethylcyclobutane-1,2-diol

“…The title compound was prepared according to a published procedure (Corey et al, 1976) upon pinacolic coupling of hexane-2,5-dione by means of amalgamated magnesium ®lings and titanium tetrachloride in tetrahydrofuran. After an aqueous alkaline work-up, extraction with diethyl ether and subsequent distillation yielded the desired product, which had already crystallized in the cooler of the distillation head (m.p.…”

Synthesis of OH-functionalized poly(p-xylylene)s by reductive coupling polymerization of aromatic dialdehydes with catalytic amounts of divalent samarium compounds

“…Mg metal was used as turnings and in some cases was activated by vigorous stirring with catalytic amounts of I 2 or C 2 H 4 Br 2 following a published procedure [17]. Amalgamated Mg was prepared by the reaction of commercial Mg powder with HgCl 2 in dry THF [18]. Monomers were prepared as described previously [5].…”