New radiopaque polyHEMA‐based hydrogel particles

Horák, Daniel; Metalová, M.; Rypáček, F.

doi:10.1002/(sici)1097-4636(199702)34:2<183::aid-jbm7>3.3.co;2-b

Cited by 16 publications

(33 citation statements)

References 4 publications

(10 reference statements)

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“…One well-known solution, especially in the case of dental and bone cements, is the incorporation of inorganic additives, such as barium sulphate or zirconium dioxide particles. In the case of methacrylic bone cements, it has been reported that these particles diminish the mechanical properties (especially fatigue life) due to the creation of interfaces between the polymeric matrix and the inorganic radio-opacifying particles [1,[7][8][9][10][11][12]. In addition, the release of such particles has been found to be deleterious to bone since they activate bone resorption [13].…”

Section: Introductionmentioning

confidence: 99%

Chemical structure of methylmethacrylate-2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate copolymer, radio-opacity, in vitro and in vivo biocompatibility

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Chemical structure of methylmethacrylate-2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate copolymer, radio-opacity, in vitro and in vivo biocompatibility

et al. 2008

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“…This approach led to radiopaque polymers that demonstrated biocompatibility [30][31][32]. Visibility under X-ray imaging such as fluoroscopy or computerized tomography requires radiopaque formulations.…”

Section: Radiopaque Polymersmentioning

confidence: 99%

Biomaterials for Injectable Therapeutic Implants

Jordan¹,

Rüfenacht²,

Iselin³

et al. 2005

Chimia

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Injectable biomaterials that have the ability to form semi-solid implants in situ are of keen interest for therapeutic applications. The materials may be used to fill in pathological vascular spaces or be designed to possess functional properties such as being radiopaque for an improved visibility during image-guided minimally invasive interventions, or induce a localized biological activity. Among the variety of solidification principles that may be used to produce implants in situ, the precipitation of water-insoluble polymers driven by solubility changes shows some particular features that may be valuable for specific therapeutic applications. This paper reviews some of the applications of these implant-forming biomaterials in interventional radiology, urology, and oncology.

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“…Traditionally, radio‐opaque polymers have often been prepared by physically entrapping radiopacifiers 14–16. However, inorganic salts and polymers do not mix homogeneously, high concentrations of the radio‐opaque agent are necessary and leaching into body fluids by phase separation and sedimentation makes the radio‐opacity temporary and may lead to potential systemic toxicity 15, 17. Covalently bonded radio‐opaque polymeric biomaterials are generally created through the polymerization of an aromatic iodine conjugated to vinylic toxicity 15, 18.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of radio‐opaque thermosensitive poly[N‐isopropylacrylamide‐2,2′‐(ethylenedioxy)bis(ethylamine)‐2,3,5‐triiodobenzamide]

Leon

Lee

Preul

et al. 2009

Polymer International

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BACKGROUND: In situ gelling polymers, like poly(N‐isopropylacrylamide) (poly(NIPAAm)), have many potential medical applications due to their biocompatibility and thermosensitivity. RESULTS: Radio‐opaque thermosensitive poly(NIPAAm) grafted with 10.7 wt% 2,2′‐(ethylenedioxy)bis(ethylamine)‐2,3,5‐triiodobenzamide was successfully synthesized and characterized. The conjugated polymer showed good visibility with X‐ray fluoroscopy. The polymer had a lower critical solution temperature of 30 °C after conjugation with triiodobenzamide as determined by cloud point determination and a transition peak temperature of 33.3 ± 0.57 °C as determined by differential scanning calorimetry. CONCLUSION: The polymer synthesized was highly visible under X‐rays, based upon the percentage incorporation of triiodobenzamide. After conjugation of the NIPAAm to the triiodobenzamide through a bis(ethylamine) linkage, the resultant polymer retained lower critical solution temperature characteristics in a temperature region that makes it physiologically useful. Copyright © 2009 Society of Chemical Industry

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New radiopaque polyHEMA‐based hydrogel particles

Cited by 16 publications

References 4 publications

Chemical structure of methylmethacrylate-2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate copolymer, radio-opacity, in vitro and in vivo biocompatibility

Chemical structure of methylmethacrylate-2-[2′,3′,5′-triiodobenzoyl]oxoethyl methacrylate copolymer, radio-opacity, in vitro and in vivo biocompatibility

Biomaterials for Injectable Therapeutic Implants

Synthesis and characterization of radio‐opaque thermosensitive poly[N‐isopropylacrylamide‐2,2′‐(ethylenedioxy)bis(ethylamine)‐2,3,5‐triiodobenzamide]

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