New radiological clues in the diagnosis of spindle cell oncocytoma of the adenohypophysis

Hasıloğlu, Zehra Işık; Ure, E.; Çomunoğlu, Nil; Tanrıöver, Necmettin; B, Öz; Gazioğlu, Nurperi; Mihmanlı, İsmail

doi:10.1016/j.crad.2016.04.022

Cited by 27 publications

(18 citation statements)

References 30 publications

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“…Although the radiological findings have been reported to be non-specific in the literature, the characteristics of magnetic resonance imaging (MRI) and the different patterns of contrast enhancement may help to recognize this rare tumor. In the recent publication from Hasiloglu and colleagues, they described the radiological findings of SCO, which include hypointense foci and linear signal-void areas on T1-weighted imaging and T2-weighted imaging [ 6 ]. On dynamic contrast-enhanced MRI (DCE-MRI) SCO shows intense contrast enhancement during the early stage of contrast administration (Hasiloglu’s sign) [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the recent publication from Hasiloglu and colleagues, they described the radiological findings of SCO, which include hypointense foci and linear signal-void areas on T1-weighted imaging and T2-weighted imaging [ 6 ]. On dynamic contrast-enhanced MRI (DCE-MRI) SCO shows intense contrast enhancement during the early stage of contrast administration (Hasiloglu’s sign) [ 6 ]. The difficulty in distinguishing SCO from other tumors such as pituitary adenoma is important, because this tumor, unlike pituitary adenoma, tends to be very vascular and prone to hemorrhage during surgical resection [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Spindle Cell Oncocytoma of the Anterior Pituitary Presenting with an Acute Clinical Course Due To Intraventricular Hemorrhage. A Case Report and Review of Literature

Osman

Wild

2017

Am J Case Rep

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Patient: Male, 56Final Diagnosis: Spindle cell oncocytoma of the adenohypophysisSymptoms: Disturbed conscious level • visual disturbancesMedication: —Clinical Procedure: Urgent craniotomySpecialty: NeurosurgeryObjective:Rare diseaseBackground:Spindle cell oncocytoma (SCO) is a rare nonfunctioning neoplasm of the adenohypophysis, and was first described in 2002. SCO has been categorized as a separate entity by the 2007 World Health Organization (WHO) and is classified as a Grade 1 tumor of the central nervous system (CNS). Review of the literature has shown that 33 cases of SCO have been reported to date, and most of them presented with a mass effect or with panhypopituitarism. However, all reported cases have described the tendency of SCO to be hypervascular on imaging and histology. We detail the first reported case of SCO to present with acute symptoms (pituitary apoplexy) and intraventricular hemorrhage, and review the literature on SCO.Case Report:We report the case of 56-year-old man who presented suddenly with a severe headache and an altered level of consciousness. Brain magnetic resonance imaging (MRI) showed a suprasellar mass with hemorrhagic areas within the tumor and bleeding into the lateral ventricle with chiasmal and hypothalamic compression. The patient underwent urgent craniotomy, tumor resection and placement of an external ventricular drain (EVD). Histology and immunohistochemistry supported a diagnosis of SCO.Conclusions:SCO of the adenohypophysis should be considered in patients who present suddenly with symptoms of pituitary apoplexy and intraventricular hemorrhage which may worsen the prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spindle Cell Oncocytoma of the Anterior Pituitary Presenting with an Acute Clinical Course Due To Intraventricular Hemorrhage. A Case Report and Review of Literature

Osman

Wild

2017

Am J Case Rep

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“…Many authors have described the radiologic features of SCO of the sella turcica as nonspecific and generally not differentiable from pituitary adenoma. However, Hasiloglu et al recently described new radiologic signs in diagnosis of SCO of the sella turcica in three cases: (1) millimetric hypointense foci and linear signal void areas in T2-weighted imaging and (2) hypervascular features of the tumor such as early intense contrast enhancement in DCE-T1WI [10]. Reported findings of SCO of the sella turcica are distinguishable from those of a typical pituitary adenoma characterized by later enhancement than a normal pituitary gland.…”

Section: Discussionmentioning

confidence: 99%

Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features

Kim

Lee

Kim

et al. 2021

J Pathol Transl Med

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We present a rare case of spindle cell oncocytoma (SCO) of the sella turcica with malignant histologic features and rapid progression. A 42-year-old woman experienced bilateral blurred vision and was preoperatively misdiagnosed as having a pituitary macroadenoma on magnetic resonance imaging. After surgery, SCO was diagnosed by the histopathologic features of interlacing fascicles of spindle tumor cells with finely granular, eosinophilic cytoplasm. Focal anaplastic changes and necrosis were present. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, S-100, galectin-3, and thyroid transcription factor 1. Four months later, the tumor had progressed, and second surgery with adjuvant radiotherapy was performed; the patients remains under observation. In this report, we proposed distinctive radiologic features for differential diagnosis between SCO and other pituitary tumors.

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“…This property gives the tumor a unique radiological appearance. Hasiloglu et al [12] advocated that these MRI properties can be used in making the preoperative diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Spindle cell oncocytoma of the adenohypophysis: A case with atypical histomorphological features and early recurrence

Kandemır¹

2018

South Clin Ist Euras

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Spindle cell oncocytoma (SCO) of the adenohypophysis is an extremely rare sellar-region tumor that creates clinicopathologically relevant problems in the differential diagnosis and difficulties in patient management due to the limited data available regarding its biological behavior. A sellar/suprasellar mass was detected and surgery was performed in a 61-year-old male admitted for impaired vision. The patient was re-operated on twice due to persistence of symptoms and an increase in tumor size at the third and sixth postoperative month. The histopathological examination revealed tumor cells with oncocytic cytoplasm and spindleepithelioid morphology fascicles/layers/pseudoacinar structures. Neoplastic cells showed a positive immunoreactivity with vimentin, epithelial membrane antigen, galectin 3, thyroid transcription factor-1, and anti-mitochondrial antibodies, and a negative immunoreactivity with epithelial markers, pituitary hormones, and neuroendocrine markers. Compared with the first biopsy sample, the material obtained from recurrent lesions was histologically characterized by increased pleomorphism, atypia, and mitotic activity. Although SCO is defined as Grade I according to the current World Health Organization classification, the considerable risk of early recurrence should be taken into account, especially in cases with atypiapleomorphism and increased mytotic activity.

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New radiological clues in the diagnosis of spindle cell oncocytoma of the adenohypophysis

Cited by 27 publications

References 30 publications

Spindle Cell Oncocytoma of the Anterior Pituitary Presenting with an Acute Clinical Course Due To Intraventricular Hemorrhage. A Case Report and Review of Literature

Spindle Cell Oncocytoma of the Anterior Pituitary Presenting with an Acute Clinical Course Due To Intraventricular Hemorrhage. A Case Report and Review of Literature

Spindle cell oncocytoma of the sella turcica with anaplastic features and rapid progression in short-term follow-up: a case report with proposal of distinctive radiologic features

Spindle cell oncocytoma of the adenohypophysis: A case with atypical histomorphological features and early recurrence

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