New Quinolone Compounds from Pseudonocardia sp. with Selective and Potent Anti-Helicobacter pylori Activity: Taxonomy of Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities.

Dekker, Koen; Inagaki, Taisuke; Gootz, Thomas D.; Huang, Liang H.; Kojima, Yasuhiro; Kohlbrenner, William E.; Matsunaga, Yasue; McGuirk, Paul R.; Nomura, Etsuko; Sakakibara, Tatsuo; Sakemi, Shinichi; Suzuki, Yumiko; Yamauchi, Yuji; Kojima, Nakao

doi:10.7164/antibiotics.51.145

Cited by 67 publications

(60 citation statements)

References 14 publications

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“…5, Supplementary Table S8). Such an interaction can be theorized to happen due to an antimicrobial activity that Pseudonocardina is known to have 43 . These interpretations show that SparCC computed taxonomic correlations can therefore provide reasonably relevant targets for hypothesis building and evaluation of co-operative and competitive interactions in the environment.…”

Section: Resultsmentioning

confidence: 99%

Bioinformatic Approaches Including Predictive Metagenomic Profiling Reveal Characteristics of Bacterial Response to Petroleum Hydrocarbon Contamination in Diverse Environments

Mukherjee

Chettri

Langpoklakpam

et al. 2017

Sci Rep

121

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Microbial remediation of oil polluted habitats remains one of the foremost methods for restoration of petroleum hydrocarbon contaminated environments. The development of effective bioremediation strategies however, require an extensive understanding of the resident microbiome of these habitats. Recent developments such as high-throughput sequencing has greatly facilitated the advancement of microbial ecological studies in oil polluted habitats. However, effective interpretation of biological characteristics from these large datasets remain a considerable challenge. In this study, we have implemented recently developed bioinformatic tools for analyzing 65 16S rRNA datasets from 12 diverse hydrocarbon polluted habitats to decipher metagenomic characteristics of the resident bacterial communities. Using metagenomes predicted from 16S rRNA gene sequences through PICRUSt, we have comprehensively described phylogenetic and functional compositions of these habitats and additionally inferred a multitude of metagenomic features including 255 taxa and 414 functional modules which can be used as biomarkers for effective distinction between the 12 oil polluted sites. Additionally, we show that significantly over-represented taxa often contribute to either or both, hydrocarbon degradation and additional important functions. Our findings reveal significant differences between hydrocarbon contaminated sites and establishes the importance of endemic factors in addition to petroleum hydrocarbons as driving factors for sculpting hydrocarbon contaminated bacteriomes.

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Section: Resultsmentioning

confidence: 99%

Bioinformatic Approaches Including Predictive Metagenomic Profiling Reveal Characteristics of Bacterial Response to Petroleum Hydrocarbon Contamination in Diverse Environments

Mukherjee

Chettri

Langpoklakpam

et al. 2017

Sci Rep

121

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“…Therefore, it seems likely that quinolone antibiotics were present in nature before the widespread use of man-made quinolones. In fact, many quinolone compounds have been reported as natural products of animals, plants and bacteria [27] and some of them are reported to have antimicrobial activities [28]. Therefore, it is not surprising that certain bacteria producing nybomycins arose in the soil to compete with a substantial number of quinolone-resistant bacteria carrying quinolone-insensitive DNA gyrase [26].…”

Section: Discussionmentioning

confidence: 98%

Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature

Hiramatsu

Igarashi

Morimoto

et al. 2012

International Journal of Antimicrobial Agents

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By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu 50. The mutants, occurring at an extremely low rate (<1 × 10(-11)/generation), were found to have their gyrA genes back-mutated and to have lost quinolone resistance. Here we describe nybomycin as the first member of a novel class of antibiotics designated 'reverse antibiotics'.

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“…Owing to their structural similarity to vitamin K, they act as potent inhibitors of electron transport in the respiratory chain. [2] The structurally related isoprenylated quinoline antibiotics are potent growth inhibitors of Helicobacter pylori, [8] while two members of the 4-hydroxy-2-alkylquinoline family (HAQs), 3,4-dihydroxy-2-heptylquinoline (PQS) [9] and 4-hydroxy-2-heptylquinoline, function as signaling molecules in cell-cell communication in Pseudomonas aeruginosa. [10] HAQ biosynthesis has been shown to result from the "head-to-head" condensation of anthranilic acid (1) and bketo fatty acids.…”

mentioning

confidence: 99%

A Type II Polyketide Synthase from the Gram‐Negative Bacterium Stigmatella aurantiaca Is Involved in Aurachin Alkaloid Biosynthesis

et al. 2007

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New Quinolone Compounds from Pseudonocardia sp. with Selective and Potent Anti-Helicobacter pylori Activity: Taxonomy of Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities.

Cited by 67 publications

References 14 publications

Bioinformatic Approaches Including Predictive Metagenomic Profiling Reveal Characteristics of Bacterial Response to Petroleum Hydrocarbon Contamination in Diverse Environments

Bioinformatic Approaches Including Predictive Metagenomic Profiling Reveal Characteristics of Bacterial Response to Petroleum Hydrocarbon Contamination in Diverse Environments

Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature

A Type II Polyketide Synthase from the Gram‐Negative Bacterium Stigmatella aurantiaca Is Involved in Aurachin Alkaloid Biosynthesis

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