New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2

Abstract

Graphical abstract A series of quinolone-triazole conjugates synthesized as potential antiviral agents for SARS-CoV2. Some of the conjugates are more potent than the standards.

New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS‐CoV‐2

“…Antiviral properties of compounds 5 a – g , 12 a – k , and 16 were determined against SARS‐CoV‐2 utilizing the standard protocol. [ 14 , 26 , 27 , 28 ] Favipiravir was used as a standard reference (positive control) for the study. Cytotoxic properties were also determined against the normal cell line VERO‐E6 by the standard MTT technique to evaluate the therapeutical/selectivity index of the tested compounds.…”

“…[8][9][10][11][12][13] Recently, we have reported a set of quinoline-triazole conjugates and some of them are showing promising activity against SARS-CoV-2. [14] In continuation of our drug development approach, we have utilized "click' chemistry" and "benzotriazole chemistry" in synthesizing new pyrazine-based conjugates as potential antiviral drug candidates for SARS-CoV-2. We have also synthesized another set of hybrid conjugate of pyrazine and benzothiazole using amino acids as linkers.…”

Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties

“…The anti-SARS-CoV-2 properties of the synthesized aspirin-curcumin mimic conjugates were determined by the standard technique ( Table 4 , Fig. 6 ) [79] , [85] , [86] . Generally, all the synthesized agents (compounds 5c , 5f and 5j are exceptions) show potent anti-SARS-CoV-2 properties (IC 50 = 1.659-8.828 µ M) relative to the standard references used (IC 50 = 36.92, 24.98 µ M for hydroxychloroquine and chloroquine, respectively).…”

Synthesis, Antibacterial Evaluation, and Computational Studies of a Diverse Set of Linezolid Conjugates

“…The synthesized linezolid conjugates (3a-k, 5a-f, 7a-c, 9a-c, 11a-f, 13, and 15) were subjected for antimicrobial properties determination against Gram-positive (Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633) and Gram-negative (Pseudomonas aeruginosa ATCC 15692, Escherichia coli ATCC 47076) bacteria by the standard technique [29,30]. From the antimicrobial properties revealed (Table 1), it is noticeable that the synthesized agents still possess better activity towards the tested Gram-positive bacteria than the Gram-negative ones in similar behavior to their parent antibiotic (standard reference, linezolid).…”