New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies
Wael A. A. Fadaly,
Taha H. Zidan,
Nesma M. Kahk
et al.
Abstract:Two new series of pyrazolyl-thiazolidinone/thiazole derivatives
16a–b
and
18a–j
were synthesised, merging the scaffolds of celecoxib and dasatinib. Compounds
16a
,
16b
and
18f
inhibit
COX-2
with S.I. 134.6, 26.08 and 42.13 respectively (celecoxib S.I. = 24.09). Compounds
16a,
16b,
18c,
18d
and
18f
… Show more
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