“…Multiple computational models have been established for identifying a chemical's genotoxic potential, triggered over 25 years ago by the publication of the Ashby-Tennant alerts in 1991 (Ashby and Tennant, 1991), followed by software such as VEGA (Fjodorova et al, 2010), ToxTree (Patlewicz et al, 2008), the OECD QSAR Toolbox (OECD, 2015c) and LAZAR (Maunz et al, 2013;Lo Piparo et al, 2014), which are all available free of charge. Other, (semi)commercial, models include MultiCASE 5 , TOPKAT 6 , HazardExpert 7 , LeadScope 8 and DEREK-Nexus 3 .…”