New Prospects in Nano Phased Co-substituted Hydroxyapatite Enrolled in Polymeric Nanofiber Mats for Bone Tissue Engineering Applications

Mosaad, Kareem E.; Shoueir, Kamel R.; Saied, Ahmed H.; Dewidar, Montasser

doi:10.1007/s10439-021-02810-2

Cited by 16 publications

(3 citation statements)

References 182 publications

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“…Natural or synthetic nanofiber-based electrospun polymers, graphene oxide or organic modifiers, such as ethylenediaminetetraacetic acid, polyethylene glycol, and cetyltrimethylammonium bromide, are used in the reinforcement of nanohydroxyapatite and synthesis of nanocomposite materials. [55][56][57] Nano-hydroxyapatite (nHA) has gained significant attention in agriculture as a potential phosphorus fertiliser, and there exists a wide range of studies regarding increasing the functionality of nHA-based nanostructured fertilisers.…”

Section: Hydroxyapatite As Phosphorus Nanofertilisermentioning

confidence: 99%

A Novel Assessment Strategy for Nanotechnology in Agriculture: Evaluation of Nanohydroxyapatite as an Alternative Phosphorus Fertiliser

Avşar¹

2022

Kemija U Industriji

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Phosphorus, provided by phosphorus fertilisers, is one of the essential nutrients for the healthy growth of plants. Phosphate rocks are strategic resources for phosphorus in agriculture and their supply will become very limited in the near future. As a raw material, phosphorus availability shows a decreasing trend over the last decades upon excessive consumption of phosphate rocks. Moreover, excessive application of conventional phosphorus fertilisers is the primary driving force for eutrophication. Utilisation of engineered nanomaterials in agriculture provides precise delivery of nutrients, together with decreasing the negative environmental impacts of excessive usage of mineral fertilisers. Studies on enhancing the phosphorus uptake efficiency have priority in order to maintain agricultural productivity. Hydroxyapatite nanoparticles can be an innovative approach as a new group of phosphorus fertilisers, offering promising potential for enhancement of agronomic yield and reduction of eutrophication. This study provides a brief review of novel approaches for developing more strategic and efficient routes for phosphorus uptake upon hydroxyapatite utilisation in order to improve crop production.

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Section: Hydroxyapatite As Phosphorus Nanofertilisermentioning

confidence: 99%

A Novel Assessment Strategy for Nanotechnology in Agriculture: Evaluation of Nanohydroxyapatite as an Alternative Phosphorus Fertiliser

Avşar¹

2022

Kemija U Industriji

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“…For hard tissue (e.g., joint replacement), the utilization of long fibers (hydrogel and bone scaffold), known as nanocomposites, has an advantage over current microsized fibers. Fibrous polymer nanomaterials are largely used in hard and soft tissue replacements, as well as in tissue engineering [7,8].…”

Section: Introductionmentioning

confidence: 99%

Fractional Boundary Element Solution for Nonlinear Nonlocal Thermoelastic Problems of Anisotropic Fibrous Polymer Nanomaterials

Fahmy,

Toujani

2024

Computation

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This paper provides a new fractional boundary element method (BEM) solution for nonlinear nonlocal thermoelastic problems with anisotropic fibrous polymer nanoparticles. This comprehensive BEM solution comprises two solutions: the anisotropic fibrous polymer nanoparticles problem solution and the nonlinear nonlocal thermoelasticity problem. The nonlinear nonlocal thermoelasticity problem solution separates the displacement field into complimentary and specific components. The overall displacement is obtained using the boundary element methodology, which solves a Navier-type problem, and the specific displacement is derived using the local radial point interpolation method (LRPIM). The new modified shift-splitting (NMSS) technique, which minimizes memory and processing time requirements, was utilized to solve BEM-created linear systems. The performance of NMSS was evaluated. The numerical results show how fractional and graded parameters influence the thermal stresses of nonlinear nonlocal thermoelastic issues involving anisotropic fibrous polymer nanoparticles. The numerical findings further reveal that the BEM results correlate very well with the finite element method (FEM) and analytical results, demonstrating the validity and correctness of the proposed methodology.

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“…One innovative approach that is being explored in tissue engineering consists of a synergic strategy that combines spheroids and scaffolds to achieve better biomechanical properties, higher cell density, and extracellular matrix production, resulting in an improvement in functionality of the final construct [17]. In this context, nanostructured hydroxyapatite scaffolds are being highly explored for bone tissue engineering applications due to their high osteoinductive potential [18,19]. These scaffolds can also be 3D printed using an extrusion-based technique to develop more versatile and custom-sized scaffolds that will fit better into a patient's bone defect, thereby improving the bone regeneration process [20,21].…”

Section: Introductionmentioning

confidence: 99%

A Synergic Strategy: Adipose-Derived Stem Cell Spheroids Seeded on 3D-Printed PLA/CHA Scaffolds Implanted in a Bone Critical-Size Defect Model

Kronemberger,

Palhares,

Rossi

et al. 2023

JFB

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Bone critical-size defects and non-union fractures have no intrinsic capacity for self-healing. In this context, the emergence of bone engineering has allowed the development of functional alternatives. The aim of this study was to evaluate the capacity of ASC spheroids in bone regeneration using a synergic strategy with 3D-printed scaffolds made from poly (lactic acid) (PLA) and nanostructured hydroxyapatite doped with carbonate ions (CHA) in a rat model of cranial critical-size defect. In summary, a set of results suggests that ASC spheroidal constructs promoted bone regeneration. In vitro results showed that ASC spheroids were able to spread and interact with the 3D-printed scaffold, synthesizing crucial growth factors and cytokines for bone regeneration, such as VEGF. Histological results after 3 and 6 months of implantation showed the formation of new bone tissue in the PLA/CHA scaffolds that were seeded with ASC spheroids. In conclusion, the presence of ASC spheroids in the PLA/CHA 3D-printed scaffolds seems to successfully promote bone formation, which can be crucial for a significant clinical improvement in critical bone defect regeneration.

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New Prospects in Nano Phased Co-substituted Hydroxyapatite Enrolled in Polymeric Nanofiber Mats for Bone Tissue Engineering Applications

Cited by 16 publications

References 182 publications

A Novel Assessment Strategy for Nanotechnology in Agriculture: Evaluation of Nanohydroxyapatite as an Alternative Phosphorus Fertiliser

A Novel Assessment Strategy for Nanotechnology in Agriculture: Evaluation of Nanohydroxyapatite as an Alternative Phosphorus Fertiliser

Fractional Boundary Element Solution for Nonlinear Nonlocal Thermoelastic Problems of Anisotropic Fibrous Polymer Nanomaterials

A Synergic Strategy: Adipose-Derived Stem Cell Spheroids Seeded on 3D-Printed PLA/CHA Scaffolds Implanted in a Bone Critical-Size Defect Model

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