New Prospective for Redox Modulation Mediated by Organo selenium and Organotellurium Compounds

Barcellos, Angelita M.; Abenante, Laura; Sarro, Maria Teresa; Leo, Iris Di; Lenardão, Eder J.; Perin, Gelson; Santi, Claudio

doi:10.2174/1385272820666161020162113

Cited by 19 publications

(7 citation statements)

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“…In recent years, there has been great interest in studying organo-tellurium compounds containing azomethane group due to the high stability and various applications of these compounds [3,4]. The applications of organotellurium compounds have been reported in several fields [4][5][6][7][8]. Past research reported using organotellurium compounds as antioxidant agents [5,9,10], polymerization catalysts [11][12][13], antitumor and pharmaceutical agents [5,14,15], organic superconductors [3,7], synthetic intermediate [4], and ligands with many transition metal ions [3,16,17].…”

Section: Introductionmentioning

confidence: 99%

A new organotellurium compounds based on camphor, aniline and p-toluidine: preparation, characterization and theoretical study

Al-Saadawy

2021

Egypt. J. Chem.

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The present study involved the preparation of organomercury and organotellurium compounds derived from camphor and (2-amino-5-methylphenyl) mercury (II) chloride and their derivatives by a condensation reaction. Characterization of the studied compounds was carried out using infrared spectrum (IR), proton nuclear magnetic resonance spectrum ( 1 H NMR), and elemental analysis (C.H.N). The molecular structure of the organotellurium compounds was investigated using the density functional theory with hybrid functional (B3LYP) and the basis set 3-21G. Geometrical structure, HOMO surfaces, LUMO surfaces, and energy gap have been produced throughout the geometry optimization. The molecular geometry and contours for the organotellurium compounds were investigated throughout the geometrical optimization. The donor and acceptor properties have been studied by comparing the highest occupied molecular orbital energies (HOMO) of organotellurium compounds. The electronegativity, electrophilicity, Ionization potential, electron affinity, Chemical Hardness, and Chemical softness for the organotellurium compounds was calculated for the molecules under the study.

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Section: Introductionmentioning

confidence: 99%

A new organotellurium compounds based on camphor, aniline and p-toluidine: preparation, characterization and theoretical study

Al-Saadawy

2021

Egypt. J. Chem.

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“…The importance of organoselenium compounds is linked to their synthetic applications as catalysts [ 1 , 2 , 3 , 4 ] and building blocks [ 5 , 6 , 7 , 8 , 9 ], allowing for several chemo-, regio- and stereoselective transformations [ 10 , 11 , 12 , 13 , 14 , 15 ]. Although organoselenium compounds have not yet reached the pharmacy shelves, studies in vitro and in vivo have demonstrated their effectiveness against several disorders [ 16 , 17 , 18 , 19 ]. Among the successful examples, those molecules presenting an organoselenium portion embedded in an aromatic or non-aromatic cycle—i.e., the selenium-containing heterocycles—have demonstrated powerful biological activities [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis of Selenophenes and Their Derivatives

et al. 2020

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The selenophene derivatives are an important class of selenium-based heterocyclics. These compounds play an important role in prospecting new drugs, as well as in the development of new light-emitting materials. During the last years, several methods have been emerging to access the selenophene scaffold, employing a diversity of cyclization-based synthetic strategies, involving specific reaction partners and particularities. This review presents a comprehensive discussion on the recent advances in the synthesis of selenophene-based compounds, starting from different precursors, highlighting the main differences, the advantages, and limitations among them.

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“…The last few decades have seen a growing interest in the synthesis of organoselenium compounds due to some promising biological activities, reported in the recent literature [1,2,3]. Selenium is present in mammalian organisms in the form of selenoenzymes, embedded in the proteinogenic amino acid selenocysteine.…”

Section: Introductionmentioning

confidence: 99%

PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity

Jastrzębska

Mellea

Salerno

et al. 2019

IJMS

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We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation.

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New Prospective for Redox Modulation Mediated by Organo selenium and Organotellurium Compounds

Cited by 19 publications

References 0 publications

A new organotellurium compounds based on camphor, aniline and p-toluidine: preparation, characterization and theoretical study

A new organotellurium compounds based on camphor, aniline and p-toluidine: preparation, characterization and theoretical study

Recent Advances in the Synthesis of Selenophenes and Their Derivatives

PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity

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