New procedure to synthesize silver nanoparticles and their interaction with local anesthetics

Mocanu, Aurora; Pasca, Roxana-Diana; Tomoaia, Gheorghe; Garbo, Corina; Frangopol, Petre T.; Horovitz, Ossi; Tomoaia-Cotişel, Maria

doi:10.2147/ijn.s51063

Cited by 15 publications

(10 citation statements)

References 44 publications

(56 reference statements)

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“…A relationship between the color of the colloidal silver nanoparticles with the diameter (6-28 nm for yellow color) and the shape was just demonstrated in other researches [23,24]. Figure 2(B) shows the atomic force microscopy measurements of the colloidal AgNPs solution, to show the surface topography of the as-formed silver nanoparticles is homogeneous and uniformly modified on the colloidal solution to obtain a surface-based nanocomposite system like published in previous studies [23][24][25][26][27][28].…”

Section: Agnps Colloidal Dispersion Characterizationsupporting

confidence: 54%

Development of an Ethanol Biosensor Based on Silver Nanoparticles/Polyaniline/Graphite/Epoxy Composite for Friendly Analytical Application

Alhadeff¹,

Bosco²,

Pastusiak³

et al. 2019

Biosensors for Environmental Monitoring

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Electrochemical biosensors for measuring ethanol were developed in this study. Silver nanoparticles were incorporated to increase sensibility. Firstly, the transducer element was prepared with silver nanoparticles/polyaniline/graphite/epoxy composite (AgNPs/PANI/GEC) where the enzymes alcohol oxidase (AOD) and horseradish peroxidase (HRP) were immobilized by adsorption. The composition of the immobilized solution was indicated by an experimental design (85% of the bi-enzymatic solution, 10% of albumin and 5% of glutaraldehyde). The immobilization method adopted in this study showed to be highly reproducible. The values of variance and standard deviation were low (0.003 and 0.053, respectively-means of three electrodes). The linear range was 0-30 g/L (R 2 = 0.983) and the sensitivity 0.004 mA L/g. A second biosensor was made with a transducer prepared with AgNPs/PANI/GEC. A chitosan film was applied over the adsorbed enzymatic solution to avoid desorption of the immobilized enzymes. The AgNPs/PANI/GEC electrodes were characterized using cycle voltammetry and the composite surface by scanning electron microscopy. The calibration for ethanol samples with this second composite fitted in a range of 0.0-0.35 g/L (R 2 = 0.984). Square rate voltammetry was the electrochemical analytical method used to obtain the amperometric calibration curves.

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Section: Agnps Colloidal Dispersion Characterizationsupporting

confidence: 54%

Development of an Ethanol Biosensor Based on Silver Nanoparticles/Polyaniline/Graphite/Epoxy Composite for Friendly Analytical Application

Alhadeff¹,

Bosco²,

Pastusiak³

et al. 2019

Biosensors for Environmental Monitoring

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show abstract

“…The micrographs show the presence of agglomerations among the particles, which is a common characteristic irrespective of the nature of the material or the way of deposition [ 50 , 51 ]. Furthermore, it could be expected that the morphologies obtained from AFM images could be different from the actual ones as a result of drying and surface effects [ 52 ]. When the average particle diameter was determined along the arrow of the cross section (red and green, electronic supplementary material, figure S2 e – h ) it was clear that it is in accordance with the SEM and TEM observations.…”

Section: Resultsmentioning

confidence: 99%

Metal and polymer-mediated synthesis of porous crystalline hydroxyapatite nanocomposites for environmental remediation

Manatunga

Silva

et al. 2018

R. Soc. open sci.

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This study was focused on the preparation of metal and polymer-mediated porous crystalline hydroxyapatite (HAp) nanocomposites for environmental applications. Four different nano HAp systems were synthesized, namely, microwave irradiated HAp (M1), Zn doped HAp (M2), Mg-doped HAp (M3) and sodium alginate incorporated HAp (M4), and characterized using X-ray diffraction (XRD), Fourier transform infra-red spectroscopy, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, nuclear magnetic resonance (NMR), X-ray fluorescence, thermogravimetric analysis and Brunauer–Emmett–Teller (BET) analyses. Systems M1–M4 showed morphologies similar to coral shapes, polymer-like interconnected structures, sponges and feathery mycelium assemblies. Using XRD, selected area electron diffraction patterns and 1H and 31P CP/MAS solid-state NMR studies, crystallinity variation was observed from highest to lowest in the order of M4 > M1 > M3 > M2. Surface area estimates using BET isotherm reflected the highest surface area for M3, and M1 > M2 > M4. Four systems of M1–M4 were used as potential adsorbent materials for the removal of metal containing azo dye from aqueous system. Adsorption data were correlated to Freundlich and Langmuir isotherm models. According to the results, the highest capacity of 212.8 mg g−1 was exhibited by M4 having mycelium like morphology with alginate groups. This study highlights the possibility of developing HAp nanocomposites for the effective removal of dye contaminants in the environment.

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“…AFM images were obtained using an AFM JEOL 4210 equipment (JOEL GmbH, Freising, Germany), operated in tapping mode,29,41,42 using standard cantilevers with silicon nitride tips (resonant frequency in the range of 200–300 kHz, and spring constant 17.5 N/m). The surface roughness of Ti implants (uncovered or covered with HAPc composite) was expressed as the arithmetic mean, Ra, and root mean square, RMS, and was estimated using AFM.…”

Section: Methodsmentioning

confidence: 99%

<p>Enhancement of bone consolidation using high-frequency pulsed electromagnetic short-waves and titanium implants coated with biomimetic composite embedded into PLA matrix: in vivo evaluation</p>

Oltean‐Dan¹,

Dogaru²,

Tomoaia-Cotişel³

et al. 2019

IJN

Self Cite

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Purpose Bone consolidation after severe trauma is the most challenging task in orthopedic surgery. This study aimed to develop biomimetic composite for coating Ti implants. Afterwards, these implants were tested in vivo to assess bone consolidation in the absence or the presence of high-frequency pulsed electromagnetic short-waves (HF-PESW). Materials Biomimetic coating was successfully developed using multi-substituted hydroxyapatite (ms-HAP) functionalized with collagen (ms-HAP/COL), embedded into poly-lactic acid (PLA) matrix (ms-HAP/COL@PLA), and subsequently covered with self-assembled COL layer (ms-HAP/COL@PLA/COL, named HAPc). Methods For in vivo evaluation, 32 Wistar albino rats were used in four groups: control group (CG) with Ti implant; PESW group with Ti implant+HF-PESW; HAPc group with Ti implant coated with HAPc; HAPc+PESW group with Ti implant coated with HAPc+HF-PESW. Left femoral diaphysis was fractured and fixed intramedullary. From the first post-operative day, PESW and HAPc+PESW groups underwent HF-PESW stimulation for 14 consecutive days. Biomimetic coating was characterized by XRD, HR-TEM, SEM, EDX and AFM. Results Osteogenic markers (ALP and osteocalcin) and micro-computed tomography (CT) analysis (especially bone volume/tissue volume ratio results) indicated at 2 weeks the following group order: HAPc+PESW>HAPc≈PESW ( P >0.05) and HAPc+PESW>control ( P <0.05), indicating the higher values in HAPc+PESW group compared to CG. The fracture-site bone strength showed, at 2 weeks, the highest average value in HAPc+PESW group. Moreover, histological analysis revealed the most abundant COL fibers assembled in dense bundles in HAPc-PESW group. At 8 weeks, micro-CT indicated higher values only in HAPc+PESW group vs CG ( P <0.05), and histological results showed a complete-healed fracture in groups: HAPc+PESW, HAPc and PESW, but with more advanced bone remodeling in HAPc+PESW group. Conclusion Using Ti implants coated by HAPc jointly with HF-PESW stimulation positively influenced the bone consolidation process, especially in its early phase, thus potentially providing a superior strategy for clinical applications.

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New procedure to synthesize silver nanoparticles and their interaction with local anesthetics

Cited by 15 publications

References 44 publications

Development of an Ethanol Biosensor Based on Silver Nanoparticles/Polyaniline/Graphite/Epoxy Composite for Friendly Analytical Application

Development of an Ethanol Biosensor Based on Silver Nanoparticles/Polyaniline/Graphite/Epoxy Composite for Friendly Analytical Application

Metal and polymer-mediated synthesis of porous crystalline hydroxyapatite nanocomposites for environmental remediation

<p>Enhancement of bone consolidation using high-frequency pulsed electromagnetic short-waves and titanium implants coated with biomimetic composite embedded into PLA matrix: in vivo evaluation</p>

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