New prebiotics by ketone donation

Satoh, Takumi

doi:10.1016/j.tem.2023.05.001

Cited by 8 publications

(2 citation statements)

References 63 publications

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“…However, the exact mechanism by which gut flora interact with hepatically derived ketone bodies remains less understood. Notably, the gut-produced short chain fatty acid butyrate shares similarities with β-hydroxybutyrate and has been considered as a potential supplement for ASD [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder

Allan,

Yamamoto,

Kunihiro

et al. 2024

Nutrients

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In this interventional pilot study, we investigated the effects of a modified ketogenic diet (KD) on children with autism spectrum disorder (ASD). We previously observed improved behavioral symptoms in this cohort following the KD; this trial was registered with Clinicaltrials.gov (NCT02477904). This report details the alterations observed in the microbiota, inflammation markers, and microRNAs of seven children following a KD for a duration of 4 months. Our analysis included blood and stool samples, collected before and after the KD. After 4 months follow up, we found that the KD led to decreased plasma levels of proinflammatory cytokines (IL-12p70 and IL-1b) and brain-derived neurotrophic factor (BDNF). Additionally, we observed changes in the gut microbiome, increased expression of butyrate kinase in the gut, and altered levels of BDNF-associated miRNAs in the plasma. These cohort findings suggest that the KD may positively influence ASD sociability, as previously observed, by reducing inflammation, reversing gut microbial dysbiosis, and impacting the BDNF pathway related to brain activity.

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Section: Introductionmentioning

confidence: 99%

Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder

Allan,

Yamamoto,

Kunihiro

et al. 2024

Nutrients

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“…Duan et al reported that the administration of PHB to Litopenaeus vannamei increased the abundance of bacteria, such as Bacillus , Lactobacillus , Lactococcus , Clostridium , and Bdellovibrio and had protective effects against infection 24 . It has already been reported that PHB exerts prebiotic actions associated with enhancing SCFA production in mammals such as mice, rats, and pigs 25–27 . However, it remains unclear whether the prebiotic effects of PHB on mammals selectively increase SCFA‐producing bacteria and alleviate obesity.…”

Section: Introductionmentioning

confidence: 99%

Prebiotic effect of poly‐D‐3‐hydroxybutyrate prevents dyslipidemia in obese mice

Mishima,

Takeda,

Nagane

et al. 2023

The FASEB Journal

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Obesity is a global health problem caused by genetic, environmental, and psychological factors and is associated with various health disorders. As such, there is a growing focus on the prevention of obesity and related diseases. The gut microbiota plays a crucial role in these diseases and has become a therapeutic target. Prebiotics, such as poly‐d‐3‐hydroxybutyric acid (PHB), have gained attention for their potential to alter the gut microbiota, promote beneficial bacterial growth, and alleviate obesity. In this study, we examined the prebiotic effects of PHB in obese mice. We found that, in C57BL/6N mice, PHB reduced blood lipid levels. Analysis of the intestinal microflora also revealed an increase in short‐chain fatty acid‐producing bacteria. When PHB was administered to obese mice, subcutaneous fat and dyslipidemia were reduced, and the number of beneficial bacteria in the intestinal microflora increased. Furthermore, fatty degradation and oxidative stress were suppressed in the liver. PHB regulates gut bacterial changes related to obesity and effectively inhibits dyslipidemia, suggesting that it could be a prebiotic agent for curing various obesity‐related diseases. In summary, PHB increases the beneficial gut microbiota, leading to an alleviation of obesity‐associated dyslipidemia.

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