New potently bioactive alkaloids from Crinum erubescens

Abstract

Antimalarial bioassay-guided fractionation of the swamp lily Crinum erubescens led to the isolation of four compounds with potent antiplasmodial activity. Compounds 1 and 2 were determined from their spectroscopic data to be the known pesticidal compound cripowellin A and the known pesticidal and antiproliferative compound cripowellin B. 1D and 2D-NMR techniques were used to determine the identities of 3 and 4 as the new compounds cripowellin C and D. A fifth compound was identified as the known alkaloid hippadine, which was inactive against Plasmodium falciparum. The antiplasmodial IC50 values of compounds 1 – 4 were determined to be 30 ± 2, 180 ± 20, 26 ± 2, and 260 ± 20 nM, respectively, and their antiproliferative IC50 values against the A2780 human ovarian cancer cell line were 11.1 ± 0.4, 16.4 ± 0.1, 25 ± 2, and 28 ± 1 nM.

Alkaloids of Amaryllidaceae as Inhibitors of Cholinesterases (AChEs and BChEs): An Integrated Bioguided Study

“…Galanthamine, unlike other drugs, is a natural product extracted from plants of the Amaryllidaceae family (Ortiz et al, 2012;Torras-Claveria et al, 2013). In addition to galanthamine, Amaryllidaceae plants produce a series of alkaloids that are unique to these taxa called Amaryllidaceae alkaloids, and they have a wide range of interesting physiological effects (Osorio et al, 2008;Presley et al, 2016). The wide distribution of the species in this family and their chemical variety, with now more than 500 identified alkaloids ( Jin et al, 2013;He et al, 2015), is an example of the biological and pharmacological potential of the family.…”

Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity

“…Amaryllidaceae plants have been studied for their potential application as a source of anticancer, anti-inflammatory, antimicrobial, anti-parasitic and anticholinesterase activities (12). In fact they have been used for centuries as part of traditional treatments for fever, swelling, cancer or malaria (12).…”

Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity.

“…In this regards, members of the family Amaryllidaceae have attracted considerable attention in the last few years due to their unique alkaloid composition with multiple biological activities (11). Amaryllidaceae plants have been studied for their potential application as a source of anticancer, anti-inflammatory, antimicrobial, antiparasitic and anticholinesterase activities (12). In fact they have been used for centuries as part of traditional treatments for fever, swelling, cancer or malaria (12).…”

“…Amaryllidaceae plants have been studied for their potential application as a source of anticancer, anti-inflammatory, antimicrobial, antiparasitic and anticholinesterase activities (12). In fact they have been used for centuries as part of traditional treatments for fever, swelling, cancer or malaria (12). Remarkably, in 2001 the Food and Drug Administration (FDA) approved the use of galanthamine (trade name Razadyne), an alkaloid identified from the Amaryllidaceae plant Galanthus woronowi, to treat Alzheimer´s disease (13).…”