New potent inhibitors of tyrosinase: Novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site

Substituted oxadiazoles: a patent review (2010 – 2012)

“…Therefore, more facile routes to 2,5-diaryl(alkyl)-1,3,4-oxadiazoles under milder conditions are still needed. In recent years, (N-isocyanimine) triphenylphosphorane (10) has been found to be a versatile reagent for the construction of nitrogen-containing heterocyclic scaffolds. Authors reported preparation of the substituted 1,3,4-oxadiazoles using compound 10 as the starting material via intramolecular aza-Wittig condensation (Scheme 2) [17][18][19][20][21][22][23][24].…”

“…Compounds containing oxadiazoles rings have been studied for biological activities such as antiviral [2,3], antimicrobial [4], anticancer [5,6], antihypertensive activity [7], neuroprotective activity [8], hypolipidemic activities [9], inhibition of tyrosinase [10] and anticonvulsant activity [11,12]. They are also useful intermediates in organic synthesis and widely employed as electron transporting and hole-blocking materials [13].…”

Biological Activity of 5-(2,3,4-Pyridyl)-1,3,4-Oxadiazol-2- Thiones and Their Derivatives.

“…U.Ghani and authors [30] studied tyrosinase inhibition by oxadiazolthione 1 and its activity Antibacterial activity, as well as the minimum inhibitory concentration (MIC) for 5-(β-pyridyl)-1,3,4-oxadiazol-2-thione 2 studied in vitro by M. Zareef et al [31] in bacteria of…”

Heterocyclic compounds based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)-furanone: Anti-avian influenza virus (H5N1) activity / Heterociklički derivati 3-(4-bromfenil) azo-5-fenil-2(3H)-furanona: Djelovanje na virus ptičje gripe (H5N1)

“…Cells were then infected with 100 µL of stock virus. After the virus adsorption period on cells of 2 hours at 37°C, the virus was removed and serial dilutions (10,20, 40 µg µL -1 ) of the tested compounds were added, then incubated with infected cells using maintenance DMEM with 2 % FBS (100 µl per well) at 37°C for 3 days of monitoring until complete CPE was observed in the infected and untreated virus control.…”

“…Keywords: furanone, pyrazole, pyridazinone, oxadiazole, triazole, anti-avian influenza virus (H5N1) acetic transaminase (GOT) and glutamate pyruvate transaminase (GPT) enzymes, inhibition of gamma-glutamyl transpeptidase (g-GT) enzyme activity (9) and potent inhibition of tyrosine (10). On the other hand, substituted 1,3,4-oxadiazoles exhibit fungicidal (11), antimicrobial and antitubercular activity (12).…”