New possibilities for potentiating the effects of antidepressants of the group of selective serotonin reuptake inhibitors by the regulatory peptide Selank in the treatment of anxiety and depressive disorders

Вербенко, В А; Shakina, T.

doi:10.29296/25877305-2019-10-16

Vrach

2019

DOI: 10.29296/25877305-2019-10-16

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New possibilities for potentiating the effects of antidepressants of the group of selective serotonin reuptake inhibitors by the regulatory peptide Selank in the treatment of anxiety and depressive disorders

В А Вербенко¹,

T. Shakina²

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Cited by 2 publications

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The features of clinical and anamnestic indicators, cognitive function, quality of life, and psychological status in patients with various stages of chronic lower extremity ischemia

Makarov,

Smirnov,

Danilchenko

2023

Vrach

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Objective. To estimate the frequency of risk factors and the features of the psychosocial status in patients with atherosclerosis of the lower extremity arteries. Subjects and methods. The investigation prospectively included 198 patients with atherosclerosis of the lower extremity arteries. The patients’ mean age was 67.9±8.0 years. Data copying, questioning, instrumental and analytical methods were used to study the patients’ clinical and anamnestic indicators. The survey was conducted using the SF-36 questionnaire and the SpielbergerKhanin test, Mini-Mental State Examination (MMSE), and Morisky-Green scales. Depending on the stage of ischemia, according to the Pokrovsky-Fontaine classification, the investigators formed two investigation groups: 1) 127 patients with Stage 0–IIA ischemia; 2) 71 patients with Stage IIB-IV ischemia. Results. There was a male preponderance in both groups: 106 men in Group 1 (p=0.03) and 52 in Group 2 (p=0.026). The number of smokers was statistically significantly higher in Group 2 than in Group 1 (37.0 and 49.0%, respectively; p=0.05). No statistically significant differences in diabetes were found between the groups. Systolic blood pressure was also higher in Group 2 than in Group 1 (136.3±15.3 and 130.7±12.9 mm Hg, respectively; p=0.0015). Analysis of physical (p = 0.00019) and psychosocial (p=0.0415) states revealed lower rates in Group 2. Conclusion. The findings suggest that Group 2 patients had more severe clinical, physical, and psychosocial conditions, which indicates the need to attract a psychologist for patients with more severe ischemia, as well as that to more carefully monitor hemodynamic parameters and to correct modifiable risk factors in both groups.

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The features of clinical and anamnestic indicators, cognitive function, quality of life, and psychological status in patients with various stages of chronic lower extremity ischemia

Makarov,

Smirnov,

Danilchenko

2023

Vrach

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Post-Covid Syndrome, Possibilities for Therapy of Asthenic Disorders With Selank

Pogodina,

Nikiforova

2024

Vrach

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Post-COVID syndrome develops after a COVID-19 infection, and is also observed in cases of mild or asymptomatic course of the disease. The most common symptoms of bridge syndrome are asthenia and decreased performance, with further development of cognitive deficit. Taking into account the leading role of immune disorders in the pathogenesis of COVID-19, the use of immunotropic drugs that have both direct activity in relation to immune interactions and those that work indirectly through the reduction of post-stress reactions that can maintain immune dysfunction seems promising. In this regard, Selank is of interest, a peptide created on the basis of the immune regulator tafcin, which has proven itself well in the treatment of a wide range of neurotic and neurosis–like disorders. Objective. To study the efficacy of the drug Selank in patients with complaints of asthenia, decreased performance and emotional disorders that developed after COVID-19 infection. Material and methods. The study included 64 patients divided into 2 groups: Group 1 (n=32) – patients received neuroprotective complex (cholitilin, mexidol, milgamma) and the drug Selank; Group 2 (n=32) – patients received neuroprotective complex (cholitilin, mexidol, milgamma) without the drug Selank. Results. The drug Selank (nasal drops, 1.5 mg) when used at a dose of 2-3 drops 4 times a day for 30 days showed a good effect in patients with asthenia and impaired mental performance. In parallel, relief of anxiety and depressive symptoms was observed. Based on the data obtained, it can be argued that Selank demonstrates a good effect when used in patients with asthenia, which developed as a result of a previous COVID-19 viral infection, with concomitant depressive and anxiety symptoms.

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New possibilities for potentiating the effects of antidepressants of the group of selective serotonin reuptake inhibitors by the regulatory peptide Selank in the treatment of anxiety and depressive disorders

Cited by 2 publications

References 8 publications

The features of clinical and anamnestic indicators, cognitive function, quality of life, and psychological status in patients with various stages of chronic lower extremity ischemia

The features of clinical and anamnestic indicators, cognitive function, quality of life, and psychological status in patients with various stages of chronic lower extremity ischemia

Post-Covid Syndrome, Possibilities for Therapy of Asthenic Disorders With Selank

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