New Possibilities for Hormonal Vaginal Treatment in Menopausal Women

Abstract

Hormonal vaginal therapy is an effective treatment option for women who experience vaginal symptoms related to hormonal changes. Estrogen and prasterone are widely used as vaginal treatments, particularly for urogenital atrophy. These symptoms may include vaginal dryness, itching, burning, and pain during sexual intercourse, all of which can significantly affect a woman’s quality of life. Previous studies have indicated that such treatment improves tissue elasticity, moisturizes the vagina, and can have a substantial impact on urine incontinence and vaginal microflora and decreases dyspareunia. Hormonal therapy is also useful and commonly used before vaginal surgical treatment. Prasterone is quite a new option for vaginal therapy in Poland and is mainly recommended for dyspareunia in menopausal women. The study related to prasterone therapy emphasizes its effectiveness and safety, making it advantageous to explore its beneficial impact. This paperwork aims to summarize the mechanism of action as well as the effects of both drugs and their beneficial action during vaginal treatment.

Experts' view on the role of oestrogens in combined oral contraceptives: emphasis on oestetrol (E4)

“…COCs with E2 may improve mental health and cognition ( 79 – 81 ), potentially easing depressive symptoms in PMDD ( 82 , 83 ). COCs can influence libido and vaginal health ( 84 , 85 ). COCs are also used to treat dermatologic conditions like hirsutism and acne due to their antiandrogenic effects ( 73 , 74 , 86 – 89 ).…”