New Polymorph Form of Dexamethasone Acetate

Nanostructural Arrangements and Surface Morphology on Ureasil-Polyether Films Loaded with Dexamethasone Acetate

“…DMA has a great tendency to form solvents [ 33 ]. Two anhydrous polymorphic forms (Form I and II) are known, and two different monohydrated polymorphs have been reported (DEX I and DEX II) [ 34 , 35 ]. In addition, DMA presents an original behavior during its crystallization in specific conditions, and the formation of whisker-like DMA crystals that very much resemble the needle-like crystal observed in Figure 5 g corresponding to a sesquihydrated form, has also been reported in the literature, for example, when saturated ethanolic solution of DMA is injected in water, or when DMA crystallized as dimethylsulfoxide (DMSO) solvate is immersed in water [ 36 , 37 , 38 ].…”

“…It is noticeable from Figure 6 that the peak at 16.8° on the unloaded u-PPO matrix is increased in the DMA-loaded film, and slightly shifted to 16.9°. It happens that this peak is coincident with a reflection from the monohydrated DMA form (DEX I) [ 34 , 36 ]. The peak at 14.0° corresponds to most intense peak in the original DMA powder diffractogram (top black curve in Figure 6 ) and can be found as a strong peak in the diffractogram of the DMA anhydrous variety (FORM II) [ 36 ], but not in this one of the monohydrated phase.…”

“…Table 2 lists the main vibrational peaks observed in the FT-IR spectra and their assignments [ 4 , 34 , 45 ]. Due to the similarity of the functional groups, most of the characteristic vibrational bands of the ureasil-polyether matrix and the DMA molecules occur in the same regions.…”

Preparation of Bioglass/Chitosan Composite incorporated with Dexamethasone by Sol-gel Method.

“…This increase in calcium concentration is induced by the release of calcium ions from the BG/CH composites. The decrease of calcium concentration from 8 up to 33 days may be due to the consumption of calcium ions through apatite formation on their surfaces [27].…”

Crystal habit optimization by means of impinging jet crystallization method

“…Polymorphism in the solid state occurs when the same molecule exists as multiple crystalline phases in the crystal lattice [74]. The most common technological factors which can induce polymorphism are i.a.…”