New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

Suzuki, Taro; Ariefta, Nanang Rudianto; Koseki, Takuya; Furuno, Hiroshi; Kwon, Eunsang; Momma, Hiroyuki; Harneti, Desi; Maharani, Rani; Supratman, Unang; Kimura, Ken; Shiono, Yoshihito

doi:10.1016/j.fitote.2018.11.017

Cited by 21 publications

(12 citation statements)

References 17 publications

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“…Five polyketides, paralactonic acids A-E 160-164 (Figure 5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes [50]. Four new polyketides, alternatains A-D 165-168 (Figure 5), were obtained from the solid substrate fermentation cultures of Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata [51].…”

Section: Ketone Compounds 221 Polyketidesmentioning

confidence: 99%

“…164 showed moderate antibacterial activity against Staphylococcus aureus NBRC 13276 (5: 24 mm) at a concentration of 100 µg/disk (MIC value: 3.2 µg/mL). Chloramphenicol was used for positive control against S. aureus (1 µg/mL) [50].…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Compounds 396-397 were evaluated for their cytotoxic activity against four human tumor cell lines (SF-268, MCF-7, HepG-2 and A549) by the SRB (Sulforhodamine B) method. As a result, compounds 396, 397 showed weak inhibitory activities against the four tumor cell lines with IC 50 Cisplatin was used as a positive control with IC 50 values of 3.39 ± 0.29 µM, 3.19 ± 0.12 µM, 2.42 ± 0.14 µM and 1.56 ± 0.08 µM against the four human tumor cell lines [41].…”

Section: Cytotoxic Activity or Anticancermentioning

confidence: 99%

“…Five human tumor cell lines were used: human myeloid leukemia HL-60, human hepatocellular carcinoma SMMC-7721, lung cancer A-549, breast cancer MCF-7, and human colon cancer SW480, which were obtained from ATCC (Manassas, VA, USA). Cisplatin was used as the positive control for the cancer cell lines (IC 50…”

Section: Cytotoxic Activity or Anticancermentioning

confidence: 99%

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Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Zheng

Zhang

et al. 2021

IJMS

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Secondary metabolites isolated from plant endophytic fungi have been getting more and more attention. Some secondary metabolites exhibit high biological activities, hence, they have potential to be used for promising lead compounds in drug discovery. In this review, a total of 134 journal articles (from 2017 to 2019) were reviewed and the chemical structures of 449 new metabolites, including polyketides, terpenoids, steroids and so on, were summarized. Besides, various biological activities and structure-activity relationship of some compounds were aslo described.

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Section: Ketone Compounds 221 Polyketidesmentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

Section: Cytotoxic Activity or Anticancermentioning

confidence: 99%

Section: Cytotoxic Activity or Anticancermentioning

confidence: 99%

See 2 more Smart Citations

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Zheng

Zhang

et al. 2021

IJMS

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“…Verkley proposed that two Coniothyrium species (C. fuckelii and C. sporulosum) should be combined into the genus Paraconiothyrium, and united as P. sporulosum [5,6]. So far, structural diverse terpenoids including brasilamides A-N [7][8][9], hawaiinolides A-G [10,11], epoxyphomalins A-E [12], sporulaminals A-B [13] and six isopimarane diterpenoid glycosides [14], and several polyketides [15][16][17][18][19][20][21][22][23][24][25][26] have been identified from the genus Paraconiothyrium.…”

Section: Introductionmentioning

confidence: 99%

Seven New Drimane-Type Sesquiterpenoids from a Marine-Derived Fungus Paraconiothyrium sporulosum YK-03

et al. 2019

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Seven new drimane-type sesquiterpenoids, namely the sporulositols A–D (1–4), 6-hydroxydiaporol (5), seco-sporulositol (6) and sporuloside (7) were isolated from the ethyl acetate extract of fermentation broth for a marine-derived fungus Paraconiothyrium sporulosum YK-03. Their structures were elucidated by analysis of extensive spectroscopic data, and the absolute configurations were established by crystal X-ray diffraction analysis and comparisons of circular dichroism data. Among them, sporulositols A–E (1–4) and seco-sporulositol (6) represent the first five examples of a unique class of drimanic mannitol derivatives, while compounds 6 and 7 may represent two new series of natural drimanes, possessing an aromatic ring with a rare 4,5-secodrimanic skeleton and an unusual CH3-15 rearranged drimanic α-D-glucopyranside, respectively. Furthermore, the origin of mannitol moiety was investigated by reliable HPLC and NMR analyses.

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Anti-multidrug-resistant Staphylococcus aureus and anti-dermatophyte activities of secondary metabolites of the endophytic fungus Penicillium brevicompactum ANT13 associated with the Algerian endemic plant Abies numidica

et al. 2023

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New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

Cited by 21 publications

References 17 publications

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

Seven New Drimane-Type Sesquiterpenoids from a Marine-Derived Fungus Paraconiothyrium sporulosum YK-03

Anti-multidrug-resistant Staphylococcus aureus and anti-dermatophyte activities of secondary metabolites of the endophytic fungus Penicillium brevicompactum ANT13 associated with the Algerian endemic plant Abies numidica

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