New polyfunctional imidazo[4,5-C]pyridine motifs: Synthesis, crystal studies, docking studies and antimicrobial evaluation

Synthesis, crystal structure, molecular docking and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine derivatives

“…Experimental procedure for the synthesis of 2-chloro-3-iodopyridin-4-amine (2) [17] A mixture of 2-chloro-4-amino pyridine 1 (20 g, 0.15 mol), potassium acetate (22.9 g, 0.23 mol) and ICl (27.7 g, 0.17 mol) in glacial acetic acid (200 mL) was heated to 70°C for 4 h. After completion of the reaction, the solvent was concentrated under reduced pressure. The residue was neutralized with 10% NaHCO 3 solution (250 mL) and extracted with two 300-mL portions of EtOAc.…”

“…The commercially available 1 (2-Chloro-4-amino pyridine) was iodinated with ICl and KOAc in glacial acetic acid at 70°C to afford a mixture of iodopyridines 2 (2-chloro-3-iodopyridin-4-amine), 3 (2-chloro-5-iodopyridin-4-amine) and 4 (2-chloro-3,5-diiodopyridin-4-amine) in the ratio 45:45:10 [17]. The iodopyridines were Symmetry transformations used to generate equivalent atoms: a +X, 3/2 À Y, À1/2 + Z. b 1 À X, 1 À Y, 1 À Z. isolated by preparative HPLC (normal phase).…”

“…Pyrrolopyridines also posses significant biological applications such as antimicrobial [5][6][7][8][9], analgesic [10], antimalarial [11], antiproliferative [12], antihypertensive [13], cannabinoid activity [14,15] and Factor VIIa inhibitors [16]. As a result of our considerable interest in the synthesis of pyridine-containing compounds and their antimicrobial activity [17], we initiated a programme directed towards the synthesis of new pyrrolopyridine compounds.…”

Synthesis, molecular docking and anti-mycobacterial evaluation of new imidazo[1,2-a]pyridine-2-carboxamide derivatives

“…Different compounds containing the moiety imidazo[1,2-a]pyridine have significant biological applications such as anti-mycobacterial [15e21], anticancer [22,23], antiviral [24e27], antimicrobial [28e30], anti-HIV [31], antiulcer [32,33], antihelminthic [34] and anticoccidial activity [35,36]. As a result of our interest in the synthesis of imidazopyridine-containing compounds and their antimicrobial activity [37], we initiated a program directed towards the synthesis of the new imidazopyridine amide derivatives. Imidazopyridine amides (IPA) are a new class of therapeutic agents against MDR and XDR tuberculosis [18e21].…”

Synthesis of novel pyridine linked to benzimidazole via sulphide and their Antioxident and Antimicrobial activity

“…Imidazo [4, 5-c] pyridine derivatives displayed promising antimicrobial activity 10 . Pyridine derivatives displayed antimicrobial activity .Anti-cancer [17][18][19] , Anti-tumor [20][21][22] , Anti-Psychotic 23 , Anti-proliferative [24][25][26] .…”