New policies for using anthelmintics in high risk groups

Allen, H. E.; Crompton, D. W. T.; Silva, Nilanthi de; LoVerde, Philip T.; Olds, G R

doi:10.1016/s1471-4922(02)02386-3

Cited by 99 publications

(69 citation statements)

References 6 publications

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“…9,10 Polyparasitic diseases due to overlapping soil-transmitted helminth (STH, hookworm, ascariasis, and trichuriasis) infections have a well-documented association with anemia and impaired growth. 7,11 As a result, current international World Health Organization (WHO)-endorsed efforts include early treatment of 2-to 5-year-old children with the antihelminthic drugs albendazole or mebendazole against STH to prevent anemia-related morbidity. [11][12][13] Crosssectional studies have also suggested synergism between Schistosoma and Plasmodium infections in risk for anemia.…”

Section: Introductionmentioning

confidence: 99%

“…7,11 As a result, current international World Health Organization (WHO)-endorsed efforts include early treatment of 2-to 5-year-old children with the antihelminthic drugs albendazole or mebendazole against STH to prevent anemia-related morbidity. [11][12][13] Crosssectional studies have also suggested synergism between Schistosoma and Plasmodium infections in risk for anemia. 14 With more sensitive testing, there is greater evidence that Schistosoma infection begins in very early childhood.…”

Section: Introductionmentioning

confidence: 99%

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Anemia Among Children Exposed to Polyparasitism in Coastal Kenya

Cojulun

Bustinduy

Sutherland

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Anemia represents a substantial problem for children living in areas with limited resources and significant parasite burden. We performed a cross-sectional study of 254 Kenyan preschool-and early school-age children in a setting endemic for multiple chronic parasitic infections to explore mechanisms of their anemia. Complete venous blood cell counts revealed a high prevalence of local childhood anemia (79%). Evaluating the potential links between low hemoglobin and socioeconomic factors, nutritional status, hemoglobinopathy, and/or parasite infection, we identified age < 9 years (odds ratio [OR]: 12.0, 95% confidence interval [CI]: 4.4, 33) and the presence of asymptomatic malaria infection (OR: 6.8, 95% CI: 2.1, 22) as the strongest independent correlates of having anemia. A total of 130/155 (84%) of anemic children with iron studies had evidence of iron-deficiency anemia (IDA), 16% had non-IDA; 50/52 of additionally tested anemic children met soluble transferrin-receptor (sTfR) criteria for combined anemia of inflammation (AI) with IDA. Children in the youngest age group had the greatest odds of iron deficiency (OR: 10.0, 95% CI: 3.9, 26). Although older children aged 9-11 years had less anemia, they had more detectable malaria, Schistosoma infection, hookworm, and proportionately more non-IDA. Anemia in this setting appears multifactorial such that chronic inflammation and iron deficiency need to be addressed together as part of integrated management of childhood anemia.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anemia Among Children Exposed to Polyparasitism in Coastal Kenya

Cojulun

Bustinduy

Sutherland

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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“…8 These chronic helminth infections can thus persist and affect each subsequent pregnancy of an individual woman. 10 The effects of maternal malaria infection during pregnancy on the infant are well defined, and malaria contributes to as much as 20% of low birthweight (LBW) deliveries, 36% of preterm deliveries, and 70% of intrauterine growth retardation in malaria-endemic areas. 11,12 Furthermore, co-infection with malaria and helminths has been found to be an important factor in adverse birth outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…Lack of adverse outcomes in animal studies, reports from mass campaigns, and a randomized trial in Uganda of ivermectin and albendazole also support treating pregnant women. 9,10 A study in Nepal, where rates of hookworm infection in pregnant women were high, suggested an improvement in maternal anemia, birthweight, and infant mortality in the group of women receiving albendazole during pregnancy. 15 However, a subsequent randomized controlled trial in Uganda did not find a difference in birth outcomes in pregnant women treated with albendazole or praziquantel.…”

Section: Introductionmentioning

confidence: 99%

Birthweight in Offspring of Mothers with High Prevalence of Helminth and Malaria Infection in Coastal Kenya

Fairley¹,

Bisanzio²,

King

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. Results of studies on the associations of maternal helminth infection and malaria-helminth co-infection on birth outcomes have been mixed. A group of 696 pregnant women from the Kwale district in Kenya were recruited and tested for malaria and helminth infection at delivery. Birthweight was documented for 664 infants. A total of 42.7% of the mothers were infected with Plasmodium falciparum, 30.6% with Schistosoma haematobium, 36.2% with filariasis, 31.5% with hookworm, and 5.9% with Trichuris trichiura; co-infection was present in 46.7%. Low birthweight (LBW) (weight 2,500 grams) was present in 15.4% of the offspring, and 8.3% had a weight z-score 2 SD below the World Health Organization mean. Only gravida, age, and locale had a significant association with LBW. The high prevalence of maternal infection coupled with a higher than expected percentage of LBW highlight a need for further investigation of the association of maternal co-infection with LBW.

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“…It also formed an Expert Committee to provide clear and strategic orientation on how to implement the recommendations (WHO 2002). A series of articles were published in internationally recognized periodicals systematizing the most recent technical and scientific information about the control of schistosomiasis and STH (Allen et al 2002a, b, 2005, Crompton et al 2003, Olds 2003, Richter 2003, Colley & Sear 2004.…”

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confidence: 99%