New Piperidinyl‐ and 1,2,3,6‐Tetrahydropyridinyl‐pyrimidine Derivatives as Selective 5‐HT_1A Receptor Agonists with Highly Potent anti‐Ischemic Effects.

Abstract

Effects. -Compound (XIa) exhibits sub-nanomolar affinity for 5-HT1A receptor with 1000-fold selectivity over both dopamine D2 and α1-adrenergic receptors and remarkable neuroprotective activity. -(KAMEI*, K.; MAEDA, N.; KATSURAGI-OGINO, R.; KOYAMA, M.; NAKAJIMA, M.; TATSUOKA, T.; OHNO, T.; INOUE, T.; Bioorg. Med. Chem. Lett. 15 (2005) 12, 2990-2993;