New phosphorus-containing spherical carbon adsorbents as promising materials in drug adsorption and release

Wiśniewski, Marek; Pacholczyk, Agnieszka; Terzyk, Artur P.; Rychlicki, Gerhard

doi:10.1016/j.jcis.2010.11.072

Cited by 29 publications

(14 citation statements)

References 16 publications

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“…In addition, mesoporous carbon materials have found many applications in biomedicine mainly due to their attractive properties, such as good biocompatibility, low toxicity and good chemical stability (Wisniewski et al, 2011). Therefore, a number of researches have described the use of porous carbon as a carrier (Kim et al, 2008;Wang et al, 2011;Ji et al, 2012) and we have previously investigated the effect of different pore structures and morphologies on drug loading and controlled release (Zhao et al, 2012a,b).…”

Section: Introductionmentioning

confidence: 99%

The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier

Wang

Zhao

et al. 2014

Drug Delivery

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Uniform mesoporous carbon spheres (UMCS) were used as a carrier to improve the bioavailability of the model drug, celecoxib (CEL). Furthermore, we investigated the mechanism responsible for the improved bioavailability of CEL. The association, adhesion and uptake of UMCS by intestinal epithelial cells were studied by transmission electron microscopy (TEM), fluorescence-activated cell sorting (FACS) and laser confocal scanning microscopy (LCSM). UMCS was found to promote cellular uptake of CEL. Drug transport in Caco-2 cell monolayers proved that UMCS can significantly reduce the rate of drug efflux and improve CEL permeability. The dissolution rate of CEL from drug-loaded samples was markedly improved compared with pure crystalline CEL; moreover, oral bioavailability of CEL loaded into UMCS was also markedly improved compared with that of commercially available capsules. UMCS indicates the advantages and potential of this method to achieve improved oral absorption by increasing the dissolution rate, cellular uptake and permeability of the drug.

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Section: Introductionmentioning

confidence: 99%

The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier

Wang

Zhao

et al. 2014

Drug Delivery

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“…On the other hand, it has been known for a long time that increasing the acidity and the hydrophilicity of activated carbons decreases the amount of aromatic molecules adsorbed from aqueous solutions (Moreno-Castilla, 2004). More specifically, some authors have linked the PA adsorption capacity with the acidity of P-containing carbons (Wiśniewski et al, 2011). In this regard, a linear relationship between the Langmuir parameters and the specific acidity (determined as the ratio between the amount of chemisorbed pyridine and S BET ) of these samples has been found, Figure 7.…”

Section: Effect Of Textural Properties and Surface Chemistry On Paracmentioning

confidence: 99%

About the Role of Porosity and Surface Chemistry of Phosphorus-Containing Activated Carbons in the Removal of Micropollutants

et al. 2019

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The preparation of phosphorus-containing activated carbons and the effect of their surface chemistry and porosity on the performance as adsorbents of paracetamol are herein reported. A parent activated carbon is prepared by chemical activation of olive stones with phosphoric acid at 500 • C and impregnation weight ratio of 3:1. This carbon is thermal treated under inert atmosphere at 900 • C, producing porosity shrinkage, loss of 20% of surface area and less oxidized phosphorus groups. In addition, our knowledge about the redox behavior of P-containing groups has allowed the controlled gasification of the parent activated carbon in diluted air atmosphere, developing wide micropores and mesopores, increasing 40% the specific surface area and producing more oxidized phosphorus groups. Adsorption of a model micropollutant, paracetamol, has been conducted over these activated carbons by using diluted aqueous solutions (<10 mg L −1 ). Batch and small-scale column experiments confirmed that the presence of narrow microporosity and surface chemistry compatible with paracetamol improves the adsorption capacity, at the point of overcoming the potential effect of additional microporosity development. Moreover, the presence of a well-developed micro-and mesoporisity combined with a low surface acidity (that increases the affinity of the activated carbon surface and paracetamol) enhances the mass transfer rate of the adsorbent, improving the small-scale column performance parameters. To sum up, this study emphasizes the key role played by surface chemistry on the applicability of P-containing activated carbon as adsorbents. These results also confirm that controlled gasification at high temperatures of P-containing activated carbons is a useful method for improving their behavior in micropollutant abatement.

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“…Porozni ugljenik sa svojim velikim adsorpcionim sposobnostima i visokom poroznošću su u širokoj upotrebi u raznim oblastima, kao što su nosači katalizatora, elektrodni materijal za baterije, industrijsko prečišćavanje, dobijanje nanokompozita itd. [18]. Prirodni materijali kao što su pirinač [19], banana i kokosovo vlakno [20], palmino ulje [21] su se koristili kao prekursori za dobijanje ugljenika.…”

Section: Uvodunclassified

Adsorpcija Metilenskog Plavog Na Aktivnom Ugljeniku Dobijenom Od Ploda Platana

Dodevski¹,

Kaluđerović²,

Krstić³

et al. 2017

JEPM

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UVODBoje se sastoje od molekula koji teško biološki degradiraju. Sa sve većim korišćenjem širokog spektra boja, zagađenje od boja otpadnih voda postaje veće i alarmantnije. Većina boja se raspadaju dajući opasne proizvode, kao što su ugljen monoksid, ugljen dioksid i hloridi vodonika koji redukuju prodor svetlosti fotosinteze [1]. Štaviše boje po sebi su same toksične u živom organizmu. Metilen plavo boja je katjonska boja koja ima različite primene u hemiji, biologiji, medicini i u bojnoj industriji. Široku primenu u prečišćavanju zagađenih površinskih, podzemnih i industrijskih voda ima komercijalni aktivni ugalj kao adsorbent. Karakteristiku dobrog adsorbenta ima zbog velike specifične površine, raspodele pora kao i sposobnosti da neselektivno u značajnoj meri adsorbuje mnoge štetne sastojke iz zagađene vode [2,3]. Aktivni ugalj se može proizvesti iz velikog broja prekursora (polaznih materijala), uključujući drvo, treset, kokosovu ljusku, poljoprivredni otpad, sintetičke smole i itd. [4]. Prekursori su izloženi različitim metodama aktiviranja kao što su fizička i hemijska u pokušaju da se dobije aktivni ugalj sa visokim stepenom adsorpcije za određenu primenu. Zbog velikog zagađenja javila se potreba za uklanjanjem i smanjivanjem zagađenja. Akcenat je stavljen na adsorpcionu tehniku. Agencija za zaštitu prirodne sredine (USEPA) navela je aktivni ugalj kao jedno od najboljih sredstava za kontrolu životne zagađeno

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New phosphorus-containing spherical carbon adsorbents as promising materials in drug adsorption and release

Cited by 29 publications

References 16 publications

The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier

The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier

About the Role of Porosity and Surface Chemistry of Phosphorus-Containing Activated Carbons in the Removal of Micropollutants

Adsorpcija Metilenskog Plavog Na Aktivnom Ugljeniku Dobijenom Od Ploda Platana

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