New Phosphoramidate Dicationic Vectors for Gene Therapy

Mével, Mathieu; Lamarche, F.; Clément, Jean-Claude; Yaouanc, Jean‐Jacques; Laurent, Pascale; Burel, Laure; Giamarchi, Philippe; Montier, Tristan; Delépine, Pascal; Lehn, Pierre; Jaffrès, Paul‐Alain; Férec, Claude

doi:10.1080/10426500701807764

Cited by 3 publications

(2 citation statements)

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“…the blood-brain barrier, [20] to embed in biological membranes, [21,22] and serve as carriers for DNA delivery (vectorization) under gene therapy. [23][24][25][26] These properties of cationic cyclodextrins, after the formation of inclusion complexes or conjugates with pharmacologically important compounds, are used in pharmacology for more efficient and targeting site delivery of the drug (prodrug) (see, for example, [27] ).…”

Section: Introductionmentioning

confidence: 99%

Dimeric Diaminocationic β-Cyclodextrin Derivatives

Shipilov¹,

Kurochkina²,

Akhlebinin³

et al. 2019

MHC

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Dimeric β-cyclodextrins derivatives being of interest as potential carriers (inclusion compounds and conjugates) of drugs for pharmacological studies in various directions have been obtained using various alkylenediamines and monohalogen substituted β-cyclodextrin derivatives. The position of substituents in carbohydrate fragments of CDs was unambiguously determined by various variants of 1 H and 13 C NMR spectroscopy and by elemental analysis.

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Section: Introductionmentioning

confidence: 99%

Dimeric Diaminocationic β-Cyclodextrin Derivatives

Shipilov¹,

Kurochkina²,

Akhlebinin³

et al. 2019

MHC

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“…the bloodbrain barrier, [3] and serve as carriers for DNA delivery (vectorization) under gene therapy. [4][5][6][7][8] We have recently shown the possibility of regiodirected esterification of unprotected β-CD by some pharmacologically important acids (ROH), namely benzoic, p-aminobenzoic (vitamin B 10 ), nicotinic (vitamin PP, vitamin B 3 ), iso-nicotinic (antivitamin PP), and 2-(4-isobutylphenyl)propionic acids (Ibuprofen, anti-fever and anti-inflammatory drug). [9] Preliminary tests of these conjugates displayed promising perspective of their subsequent pharmacological investigations.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Nanosized Monocationic β-Cyclodextrin Conjugates Containing Residues of Pharmacologically Important Acids

Shipilov¹,

Kurochkina²,

Сергиевич³

et al. 2017

MHC

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Synthesis of monocationic β-cyclodextrin derivatives

et al. 2017

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Reactions of 6-bromo-and 6-iodo-6-deoxy-β-cyclodextrin with organic amines of diverse nature afforded a series of monocationic derivatives with aminium groups located in the cyclodextrin scaffold on the side of the primary hydroxy groups. The structure and composition of the obtained cationic β-cyclodextrin derivatives were confirmed by 1 H and 13 C NMR data.Cationic cyclodextrin derivatives owing to the positive charge on the cyclodextrin matrix are capable of incorporation in biologic membranes and of penetration through biologic barriers [1-4]. They are potential objects of pharmacological studies as drug carriers and also as carriers for the DNA delivery (vectorization) in the gene therapy [3][4][5][6][7].The preparation of cationic derivatives commonly utilizes 6-azido-6-deoxy cyclodextrin derivatives that are converted into amines by treating with triphenylphosphine in aqueous ammonia [8,9]. However this method possesses a limitation since it is suitable only for the preparation of aminium cyclodextrin derivatives from primary amines.

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New Phosphoramidate Dicationic Vectors for Gene Therapy

Cited by 3 publications

References 1 publication

Dimeric Diaminocationic β-Cyclodextrin Derivatives

Dimeric Diaminocationic β-Cyclodextrin Derivatives

Synthesis of Nanosized Monocationic β-Cyclodextrin Conjugates Containing Residues of Pharmacologically Important Acids

Synthesis of monocationic β-cyclodextrin derivatives

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