New perspectives on lenticulostriate vasculopathy in neonates

Sisman, J

doi:10.1016/j.earlhumdev.2015.04.002

Cited by 1 publication

(2 citation statements)

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“…Lenticulostriate vasculopathy is a sonographic term given to ‘branching hyperechogenic lines’ in the basal ganglia seen on cranial ultrasound 11 . Isolated lenticulostriate vasculopathy is generally considered a benign finding.…”

Section: Discussionmentioning

confidence: 99%

“…Lenticulostriate vasculopathy is a sonographic term given to 'branching hyperechogenic lines' in the basal ganglia seen on cranial ultrasound. 11 Isolated lenticulostriate vasculopathy is generally considered a benign finding. Although an association between lenticulostriate vasculopathy and mineralizing angiopathy has recently been reported, 1,12,13 further research is needed to clarify whether there is a relationship between these two entities.…”

Section: Lenticulostriate Vasculopathy and Mineralizing Angiopathymentioning

confidence: 99%

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Childhood arterial ischemic stroke due to mineralizing angiopathy: an 18‐year single‐center experience

Gorodetsky

Pulcine

Krishnan

et al. 2021

Develop Med Child Neuro

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Mineralizing angiopathy is a unique, age‐specific stroke syndrome characterized by basal ganglia infarction and lenticulostriate calcification after minor head injury in early childhood. There is limited understanding of the pathophysiology, course, and clinical outcome of this syndrome. We describe the clinical and radiographical phenotype of a single‐center, consecutively enrolled cohort of children with mineralizing angiopathy from January 2002 to January 2020 and provide a comparative analysis to previously published literature. Fourteen children were identified. Previously unreported findings include: stroke onset in eight children older than 18 months; presence of basal ganglia hemorrhage in four; multifocal basal ganglia infarcts in three; presence of additional non‐basal ganglia calcifications in three; and presence of thrombophilia in one. Seven children had moderate‐to‐severe neurological deficits. There was no symptomatic stroke recurrence (mean follow‐up 3y 7mo, SD 1y 7mo). Our expanded phenotype highlights distinct characteristics of mineralizing angiopathy in children and has the potential to inform future research. Children with mineralizing angiopathy are often misdiagnosed as having a limb fracture despite normal x‐rays. A magnetic resonance imaging‐only approach may miss this entity. Non‐contrast computed tomography, in addition to MRI is recommended to identify calcifications in idiopathic arterial ischemic stroke. Most children have moderate‐to‐severe neurological sequela.

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Section: Discussionmentioning

confidence: 99%