New perspectives in the pharmacologic therapy of cardiac arrhythmias

Singh, Bramah N.; Collett, John; Chew, Christopher

doi:10.1016/0033-0620(80)90011-0

Cited by 200 publications

(36 citation statements)

References 171 publications

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“…In conscious beagles, mexiletine had stimulatory effect on the central nervous system, as has been reported previously (46,58,71). Stronger central excitatory effects, including tonic and clonic seizures, were induced by lidocaine, 10 mg/kg i.v.…”

Section: Cardiovascular and Toxicological Effectssupporting

confidence: 60%

“…Mexiletine is a class 1B Na+ channel-blocking drug and had no effect on the Ca2+ channel or adrenergic p adrenoceptors (58). Probably by increasing K + permeability (4), mexiletine slightly shortened the action potential duration of the canine Purkinje fiber (4,68,70) but not of the atrial and ventricular muscles (4,35,51,70).…”

Section: !!I -mentioning

confidence: 99%

“…Mexiletine has been shown in numerous earlier studies to suppress acute and chronic ventricular arrhythmias caused by digitalis intoxication, recent acute myo-cardial infarction, cardiac surgery, and also those of unknown etiology (10,11,34,57,58,63,64,71).…”

Section: Clinical Pharmacology Clinical Effectivenessmentioning

confidence: 99%

“…It will be approved for clinical use in the United States in the near future. Since many papers and reviews have already been published to support the effectiveness of mexiletine in arrhythmias, especially of ventricular origin (1,2,19,57,58,69,71), this chapter aims to summarize comparative studies of mexiletine with other antiarrhythmic drugs in order to clarify the pharmacological and therapeutic value of mexiletine compared to other antiarrhythmic drugs.…”

mentioning

confidence: 99%

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Mexiletine

Hashimoto¹

1986

Cardiovascular Drug Reviews

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Section: Cardiovascular and Toxicological Effectssupporting

confidence: 60%

Section: !!I -mentioning

confidence: 99%

Section: Clinical Pharmacology Clinical Effectivenessmentioning

confidence: 99%

mentioning

confidence: 99%

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Mexiletine

Hashimoto¹

1986

Cardiovascular Drug Reviews

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“…4,5 Lacidipine, a dihydropyridine derived calcium antagonist, has relative prolonged action: the administration of 4 mg once a day reduces blood pressure over 24 h with one, daily dosage. 6,7 In comparison with short-acting dihydropyridine drugs which resulted in a fluctuation in blood pressure and some side effects associated with rapid vasodilatation and sympathetic activation. 3,8,9 Regular nifedipine requires three or four doses per day to have a sustained effect over 24 h. The osmotic slow release formulation (GITS) has been developed to allow administration in one dose per day.…”

Section: Introductionmentioning

confidence: 99%

Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension

et al. 2000

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With the aim of evaluating the effects on blood pressure, platelet function and insulin sensitivity of the dihydropiridines lacidipine and nifedipine GITS, a parallel double-blind study was carried out in a group of 20 patients with mild to moderate essential hypertension. They received a placebo for 4 weeks; then were divided at random into two groups of 10 patients each. Nifedipine GITS, 30 mg and lacidipine, 4 mg, were given during 16 weeks of active treatment. Blood pressure and heart rate were measured at the clinic in supine, sitting and standing positions, 24 ؎ 1 h after the last dose. After the placebo and active phases were carried out, a platelet aggregation test was performed to determine platelet malondialdehyde production and a tolerance to 100 g of glucose by measuring glucaemia and plasma insulin.

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Aprindine therapy for refractory ventricular tachycardia

Khan¹

1983

Archives of Internal Medicine

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Aprindine hydrochloride has been extensively used in Europe for the management of ventricular and supraventricular arrhythmias. Success has been achieved even in those cases that have proven refractory to standard antiarrhythmic agents. In this report, we describe our experience with aprindine therapy in seven patients with ventricular tachycardia in whom standard antiarrhythmic agents had proven either ineffective or had caused intolerable side effects. Aprindine was effective in five cases, and it failed in two. Neurologic side effects, although common, were easily controlled with adjustment of the dose. Agranulocytosis, a rare but serious side effect, was encountered in one of our patients. Relevant literature on aprindine is reviewed.

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New perspectives in the pharmacologic therapy of cardiac arrhythmias

Cited by 200 publications

References 171 publications

Mexiletine

Mexiletine

Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension

Aprindine therapy for refractory ventricular tachycardia

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