New perspectives in cancer: Modulation of lipid metabolism and inflammation resolution

Prevete, Nella; Liotti, Federica; Amoresano, Angela; Pucci, Piero; Paulis, Amato de; Melillo, Rosa Marina

doi:10.1016/j.phrs.2017.09.024

Cited by 34 publications

(41 citation statements)

References 112 publications

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“…Many tumors display immune infiltrating cells, similar in phenotypes to those recruited during the resolution phase of wound healing 7 wherein the tissue microenvironment is enriched of leukocytes with immunosuppressive properties. This immunosuppressive context causes a block of cytotoxic T lymphocyte- or NK-mediated killing of transformed cells 8 .…”

Section: How Tumors Can Avoid Immune Recognition/eliminationmentioning

confidence: 99%

Recent advances in understanding immune phenotypes of thyroid carcinomas: prognostication and emerging therapies

Liotti¹,

Prevete²,

Vecchio³

et al. 2019

F1000Res

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Tumors modulate the host immune cells within their microenvironment to avoid recognition and elimination by our immune system, a phenotype called cancer immune escape. Different mechanisms responsible for cancer immune escape that result either in decreased tumor immunogenicity or in increased tumor immunosuppressive activity have been identified. Recently, various immunotherapeutic approaches have been developed with the aim to revert tumor immune escape. The aims of this review are to explore the immunological aspects of thyroid cancer and to assess whether these features can be exploited in the prognosis and treatment of advanced forms of this disease. Therefore, we will describe the immune landscape and phenotypes of thyroid cancer, summarize studies investigating the expression of immunomodulatory molecules, and finally describe the preclinical and clinical trials investigating the utility of immunotherapies in the management of thyroid cancer. The aim of this review is to explore the immunological aspects of thyroid cancer and to assess whether these features can be exploited in the prognosis and treatment of advanced forms of this disease. Therefore, we will describe the immune-landscape and phenotypes of thyroid cancer, we will summarize studies investigating the expression of immunomodulatory molecules, and we will finally describe the preclinical and clinical trials investigating the utility of immunotherapies in the management of thyroid cancer.

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Section: How Tumors Can Avoid Immune Recognition/eliminationmentioning

confidence: 99%

Recent advances in understanding immune phenotypes of thyroid carcinomas: prognostication and emerging therapies

Liotti¹,

Prevete²,

Vecchio³

et al. 2019

F1000Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…By the recruitment of immunosuppressive cells, decreasing the tumor immunogenicity, or through other immunosuppressive mechanisms, tumors can impair the host immune cells in TME and escape their surveillance [6]. Many tumors show the presence of immune infiltrating cells, similar to those recruited during the resolution phase of wound healing [7], causing a block of cytotoxic T lymphocyte- or NK-mediated killing of transformed cells [8]. Moreover, the presence of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) polarized toward an M2 phenotype, and tumor-associated mast cells (TAMCs) can help the tumor cells to escape from immune killing [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Immune and Inflammatory Cells in Thyroid Cancer Microenvironment

Ferrari

Fallahi

Galdiero

et al. 2019

IJMS

171

139

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A hallmark of cancer is the ability of tumor cells to avoid immune destruction. Activated immune cells in tumor microenvironment (TME) secrete proinflammatory cytokines and chemokines which foster the proliferation of tumor cells. Specific antigens expressed by cancer cells are recognized by the main actors of immune response that are involved in their elimination (immunosurveillance). By the recruitment of immunosuppressive cells, decreasing the tumor immunogenicity, or through other immunosuppressive mechanisms, tumors can impair the host immune cells within the TME and escape their surveillance. Within the TME, cells of the innate (e.g., macrophages, mast cells, neutrophils) and the adaptive (e.g., lymphocytes) immune responses are interconnected with epithelial cancer cells, fibroblasts, and endothelial cells via cytokines, chemokines, and adipocytokines. The molecular pattern of cytokines and chemokines has a key role and could explain the involvement of the immune system in tumor initiation and progression. Thyroid cancer-related inflammation is an important target for diagnostic procedures and novel therapeutic strategies. Anticancer immunotherapy, especially immune checkpoint inhibitors, unleashes the immune system and activates cytotoxic lymphocytes to kill cancer cells. A better knowledge of the molecular and immunological characteristics of TME will allow novel and more effective immunotherapeutic strategies in advanced thyroid cancer.

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“…However, in many cases, the inflammatory response is the basis of certain diseases and is an accompanying part of the diseases process. Mounting evidence has demonstrated that chronic inflammation plays an important role in initiating and progressing of various diseases, such as MetS (Reddy, Lent‐Schochet, Ramakrishnan, McLaughlin, & Jialal, 2019), CVD (Zhong et al., 2019), and cancer (Prevete et al., 2018). Here, we specifically discuss the effect of diet on inflammation.…”

Section: Application Of Ms‐based Lipidomics In Nutrition and Human Hementioning

confidence: 99%

Mass spectrometry‐based lipidomics in food science and nutritional health: A comprehensive review

Sun

Wang

Cong

et al. 2020

Comp Rev Food Sci Food Safe

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With the advance in science and technology as well as the improvement of living standards, the function of food is no longer just to meet the needs of survival. Food science and its associated nutritional health issues have been increasingly debated. Lipids, as complex metabolites, play a key role both in food and human health. Taking advantages of mass spectrometry (MS) by combining its high sensitivity and accuracy with extensive selective determination of all lipid classes, MS‐based lipidomics has been employed to resolve the conundrum of addressing both qualitative and quantitative aspects of high‐abundance and low‐abundance lipids in complex food matrices. In this review, we systematically summarize current applications of MS‐based lipidomics in food field. First, common MS‐based lipidomics procedures are described. Second, the applications of MS‐based lipidomics in food science, including lipid composition characterization, adulteration, traceability, and other issues, are discussed. Third, the application of MS‐based lipidomics for nutritional health covering the influence of food on health and disease is introduced. Finally, future research trends and challenges are proposed. MS‐based lipidomics plays an important role in the field of food science, promoting continuous development of food science and integration of food knowledge with other disciplines. New methods of MS‐based lipidomics have been developed to improve accuracy and sensitivity of lipid analysis in food samples. These developments offer the possibility to fully characterize lipids in food samples, identify novel functional lipids, and better understand the role of food in promoting healt.

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New perspectives in cancer: Modulation of lipid metabolism and inflammation resolution

Cited by 34 publications

References 112 publications

Recent advances in understanding immune phenotypes of thyroid carcinomas: prognostication and emerging therapies

Recent advances in understanding immune phenotypes of thyroid carcinomas: prognostication and emerging therapies

Immune and Inflammatory Cells in Thyroid Cancer Microenvironment

Mass spectrometry‐based lipidomics in food science and nutritional health: A comprehensive review

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