New Perspectives for MPI: A Toolbox for Tracer Research

Gehrke, Nicole; Briel, Andreas; Ludwig, Frank; Remmer, Hilke; Wawrzik, Thilo; Wellert, Stefan

doi:10.1007/978-3-642-24133-8_16

Cited by 16 publications

(13 citation statements)

References 7 publications

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“…2. FeraSpin R has been previously shown to exhibit the same MPS as Resovist [2]. The MPS amplitude of NPIO-1 exceeds that of NPIO-2 and FeraSpin R by a factor of 2.7 at the third harmonic.…”

Section: B Magnetic Particle Spectroscopymentioning

confidence: 90%

Magnetic Characterization of Clustered Core Magnetic Nanoparticles for MPI

et al. 2015

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Diagnostic imaging is of utmost importance for clinical routine and research and is also gaining more and more relevance in preclinical research. Magnetic particle imaging (MPI) as a new imaging modality may open new perspectives in the field. Iron oxide magnetic nanoparticles (MNPs) are already used as MRI contrast agents are of general interest for various other biomedical applications, and are also promising as MPI tracers. However, to provide the desired performance for MPI, it is still necessary to optimize the particles signal efficacy. Optimization remains an unexpected challenge and, as a consequence, considerable importance is being given to the research of MNPs, where efforts have been placed to understand the relation between particle structure and particle magnetic properties in more detail. In the present study, two clustered core MNPs exhibiting similar structures, but significant differences in their magnetic particle spectra, are investigated. Their static and dynamic magnetic properties are analyzed to understand the reasons for such differences as well as to gain a better insight of their relation to the particle structure.Index Terms-Diagnostic imaging, iron oxide nanoparticles, magnetic particle imaging (MPI), multicore core, tracer.

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Section: B Magnetic Particle Spectroscopymentioning

confidence: 90%

Magnetic Characterization of Clustered Core Magnetic Nanoparticles for MPI

et al. 2015

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“…The FeraSpin R particles are carboxydextran coated multicore particles, i.e. the multi-core particles consist of clusters composed of smaller nanocrystals of about 5-8 nm [10,11]. The multi-core particles exhibit a size distribution with the smallest one comprising only one nanocrystal per multi-core particle and the larger ones containing multiple nanocrystals per multi-core particle.…”

Section: Methodsmentioning

confidence: 99%

Effective particle magnetic moment of multi-core particles

Ahrentorp¹,

Astalan²,

Blomgren³

et al. 2015

Journal of Magnetism and Magnetic Materials

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“…So far, most of the MPI experiments utilize Resovist ® – a clinically approved contrast agent originally developed for magnetic resonance imaging (MRI). In addition, MPI performance, comparable to that of Resovist, was demonstrated with other tracers optimized for MRI such as FeraSpin R ™ from nanoPET Pharma GmbH[2]. It is, however, known that only a small fraction of the nanoparticles of Resovist and FeraSpin R contributes to the MPI signal.…”

Section: Introductionmentioning

confidence: 99%

Self-consistent magnetic properties of magnetite tracers optimized for magnetic particle imaging measured by ac susceptometry, magnetorelaxometry and magnetic particle spectroscopy

Ludwig

Remmer

Kuhlmann

et al. 2014

Journal of Magnetism and Magnetic Materials

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Sensitivity and spatial resolution in Magnetic Particle Imaging are affected by magnetic properties of the nanoparticle tracers used during imaging. Here, we have carried out a comprehensive magnetic characterization of single-core iron oxide nanoparticles that were designed for MPI. We used ac susceptometry, fluxgate magnetorelaxometry, and magnetic particle spectroscopy to evaluate the tracer’s magnetic core size, hydrodynamic size, and magnetic anisotropy. Our results present a self-consistent set of magnetic and structural parameters for the tracers that is consistent with direct measurements of size using transmission electron microscopy and dynamic light scattering and that can be used to better understand their MPI performance.

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New Perspectives for MPI: A Toolbox for Tracer Research

Cited by 16 publications

References 7 publications

Magnetic Characterization of Clustered Core Magnetic Nanoparticles for MPI

Magnetic Characterization of Clustered Core Magnetic Nanoparticles for MPI

Effective particle magnetic moment of multi-core particles

Self-consistent magnetic properties of magnetite tracers optimized for magnetic particle imaging measured by ac susceptometry, magnetorelaxometry and magnetic particle spectroscopy

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