New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review

Musumeci, Giuseppe; Castrogiovanni, Paola; Leonardi, Rosalia; Trovato, Francesca M.; Szychlinska, Marta Anna; Giunta, Angelo Di; Loreto, Carla; Castorina, Sergio

doi:10.5312/wjo.v5.i2.80

Cited by 131 publications

(103 citation statements)

References 56 publications

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“…Biomechanical stimulus generated by dynamic compression, during a moderate exercise, can reduce the synthesis of proteolytic enzymes, regulating the metabolic balance and preventing the progression of the disease [40,41] . Moreover, reduction in inflammation seems to be a crucial mechanism, since exercise is a potential anti-inflammatory treatment for patients with [49,50] . The 2009 American College of Sports Medicine position statement "exercise and physical activity for older adults" highlighted the lack of studies on the effects of a range of motion exercises on flexibility outcomes in older populations and also the absence of consensus about the prescription of stretching exercises [51] .…”

Section: Rheumatic Diseasesmentioning

confidence: 99%

“…It is shown that a static or dynamic exercise program can improve strength, aerobic capacity and physical performance without increasing disease activity or aggravating joint damage [48] . In cases where surgical orthopedic treatment is indicated, physiatric preparation and follow up to the intervention is necessary -rehabilitation adapted to the type of operation, the situation of the patient [49] .…”

Section: Flexibility Trainingmentioning

confidence: 99%

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Effects of exercise on physical limitations and fatigue in rheumatic diseases

Musumeci

2015

WJO

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Physical activity covers not just sports but also simple everyday movements such as housework, walking and playing. Regular exercise has a great importance in maintaining good health, indeed inactivity is a risk factor for different chronic diseases. Physical exercise can play a crucial role in the treatment of rheumatic diseases, optimizing both physical and mental health, enhancing energy, decreasing fatigue and improving sleep. An exercise program for patients with rheumatic diseases aims to preserve or restore a range of motion of the affected joints, to increase muscle strength and endurance, and to improve mood and decrease health risks associated with a sedentary lifestyle. In this editorial I describe the benefits of the exercise on physical limitations and fatigue in rheumatic diseases that seem to have a short and long-term effectiveness. A literature review was conducted on PubMed, Scopus and Google Scholar using appropriate keywords based on the present editorial.

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Section: Rheumatic Diseasesmentioning

confidence: 99%

Section: Flexibility Trainingmentioning

confidence: 99%

Effects of exercise on physical limitations and fatigue in rheumatic diseases

Musumeci

2015

WJO

Self Cite

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“…3 Recent in vitro studies indicate that the most efficient chondrogenic differentiation of chondrocyte-like progenitor cells and mesenchymal stem cells is achieved by using standard cell culture medium supplemented with growth factors like insulin-like growth factor (IGF) 1, transforming growth factor (TGF) β1 and 2, fibroblast growth factor (FGF) 2, and bone morphogenetic protein (BMP) 2. [4][5][6] It is known that IGF-1 enhances the synthesis of proteoglycans and directly decreases the degradation of proteoglycans in cartilage.…”

Section: Introductionmentioning

confidence: 99%

“…22,24 So far, a variety of different synthetic and natural materials have been investigated with respect to cartilage repair. 3,25 The main focus lies on restoring the complex structure and properties of hyaline cartilage to achieve long-term improvements in cartilage engineering. 26 Despite a high number of studies, the optimal scaffold for the repair of cartilage defects has not yet been identified.…”

Section: Introductionmentioning

confidence: 99%

“…The material has to be biocompatible, biodegradable, and bioactive. 3 Cells are expected to grow into the scaffold and start producing their own extracellular matrix, so that the defect is replenished with autologous chondrocytes and a functional hyaline cartilage-like matrix at the end. 27 Collagen-based biomaterials turned out to be well-suited; for example, scaffolds consisting of collagen type I in combination with collagen type II and HA were shown to positively influence cell attachment, migration, and proliferation as well as chondrogenic differentiation.…”

Section: Introductionmentioning

confidence: 99%

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Positive impact of IGF-1-coupled nanoparticles on the differentiation potential of human chondrocytes cultured on collagen scaffolds

Pasold

Zander

Heskamp

et al. 2015

IJN

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Purpose In the present study, silica nanoparticles (sNP) coupled with insulin-like growth factor 1 (IGF-1) were loaded on a collagen-based scaffold intended for cartilage repair, and the influence on the viability, proliferation, and differentiation potential of human primary articular chondrocytes was examined. Methods Human chondrocytes were isolated from the hyaline cartilage of patients (n=4, female, mean age: 73±5.1 years) undergoing primary total knee joint replacement. Cells were dedifferentiated and then cultivated on a bioresorbable collagen matrix supplemented with fluorescent sNP coupled with IGF-1 (sNP–IGF-1). After 3, 7, and 14 days of cultivation, cell viability and integrity into the collagen scaffold as well as metabolic cell activity and synthesis rate of matrix proteins (collagen type I and II) were analyzed. Results The number of vital cells increased over 14 days of cultivation, and the cells were able to infiltrate the collagen matrix (up to 120 μm by day 7). Chondrocytes cultured on the collagen scaffold supplemented with sNP–IGF-1 showed an increase in metabolic activity (5.98-fold), and reduced collagen type I (1.58-fold), but significantly increased collagen type II expression levels (1.53-fold; P =0.02) after 7 days of cultivation compared to 3 days. In contrast, chondrocytes grown in a monolayer on plastic supplemented with sNP-IGF-1 had significantly lower metabolic activity (1.32-fold; P =0.007), a consistent amount of collagen type I, and significantly reduced collagen type II protein expression (1.86-fold; P =0.001) after 7 days compared to 3 days. Conclusion Collagen-based scaffolds enriched with growth factors, such as IGF-1 coupled to nanoparticles, represent an improved therapeutic intervention for the targeted and controlled treatment of articular cartilage lesions.

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Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair

O’Connell

Duchi

Onofrillo

et al. 2022

Adv Healthcare Materials

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Human articular cartilage has a poor ability to self-repair, meaning small injuries often lead to osteoarthritis, a painful and debilitating condition which is a major contributor to the global burden of disease. Existing clinical strategies generally do not regenerate hyaline type cartilage, motivating research toward tissue engineering solutions. Prospective cartilage tissue engineering therapies can be placed into two broad categories: i) Ex situ strategies, where cartilage tissue constructs are engineered in the lab prior to implantation and ii) in situ strategies, where cells and/or a bioscaffold are delivered to the defect site to stimulate chondral repair directly. While commonalities exist between these two approaches, the core point of distinction-whether chondrogenesis primarily occurs "within" or "without" (outside) the body-can dictate many aspects of the treatment. This difference influences decisions around cell selection, the biomaterials formulation and the surgical implantation procedure, the processes of tissue integration and maturation, as well as, the prospects for regulatory clearance and clinical translation. Here, ex situ and in situ cartilage engineering strategies are compared: Highlighting their respective challenges, opportunities, and prospects on their translational pathways toward long term human cartilage repair.

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New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review

Cited by 131 publications

References 56 publications

Effects of exercise on physical limitations and fatigue in rheumatic diseases

Effects of exercise on physical limitations and fatigue in rheumatic diseases

Positive impact of IGF-1-coupled nanoparticles on the differentiation potential of human chondrocytes cultured on collagen scaffolds

Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair

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