New perspective on molecular markers as promising therapeutic targets in germ cell tumors

Chieffi, Paolo

doi:10.5582/irdr.2016.01007

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Aurora B As Therapeutic Target1

Aurora B and Cancer1

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2018

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Cited by 3 publications

(3 citation statements)

References 29 publications

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“…These three drugs have similar potency versus Aurora A, and Aurora B. Each induces a similar phenotype in cell-based assays, characterized by inhibition of phosphorylation of histone H3 on Ser 10 and Ser 28 , inhibition of cytokinesis, and development of polyploidy (28)(29)(30)(31)(32)(33)(34).…”

Section: Aurora B As Therapeutic Targetmentioning

confidence: 99%

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Aurora B: A new promising therapeutic target in cancer

Chieffi¹

2018

IRDR

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Section: Aurora B As Therapeutic Targetmentioning

confidence: 99%

“…However, antimitotic drugs frequently show the appearance of drug resistance, adverse side effects (neurotoxicity) and their clinical effects are not predictable. Aurora inhibitors lack neurotoxicity and could contribute to the treatment of human neoplasia (31)(32)(33)(34).…”

Section: Aurora B and Cancermentioning

confidence: 99%

Aurora B: A new promising therapeutic target in cancer

Chieffi¹

2018

IRDR

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“…Numerous new biomarkers have been found to discriminate TGCTs subtypes, standing for innovative molecular therapeutic targets. High-mobility group proteins A1 (HMGA1) and A2 (HMGA2) act as powerful diagnostic markers (12)(13)(14)(15). Really, these two proteins are diversely expressed in TGCTs in comparison with the stage of tumor differentiation (12,13).…”

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confidence: 99%