New Peptides Isolated from Marine Cyanobacteria, an Overview over the Past Decade

Mi, Yue; Zhang, Jinrong; He, Shan; Yan, Xiaojun

doi:10.3390/md15050132

Cited by 57 publications

(50 citation statements)

References 88 publications

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“…Secondary metabolites that are isolated from cyanobacteria are of greater involvement due to their unique structural scaffolds and competency to produce potent drugs with significant biological properties such as antibacterial, antifungal, anticancer, anti-tuberculosis, immunosuppressive, and anti-inflammatory. According to Vijayakumar et al and Mi et al, most of the secondary metabolites have been extracted from the genera Oscillatoriales, Lyngbya, Mooria, Okeania and Caldora [ 27 , 28 ]. However, the genera Moorea and Okeania were previously recognized, as has the polyphyly genus Lyngbya , while the genus Caldora was distinguished as Symploca .…”

Section: Chemical Diversity Of Secondary Metabolites From Cyanobacmentioning

confidence: 99%

Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review

et al. 2017

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Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increase in the number of deaths caused by cancer due to chemotherapy resistance as well. Accordingly, marine cyanobacteria, being the oldest prokaryotic microorganisms belonging to a monophyletic group, have proven themselves as being able to generate pharmaceutically important natural products. They have long been known to produce distinct and structurally complex secondary metabolites including peptides, polyketides, alkaloids, lipids, and terpenes with potent biological properties and applications. As such, this review will focus on recently published novel compounds isolated from marine cyanobacteria along with their potential bioactivities such as antibacterial, antifungal, anticancer, anti-tuberculosis, immunosuppressive and anti-inflammatory capacities. Moreover, various structural classes, as well as their technological uses will also be discussed.

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Section: Chemical Diversity Of Secondary Metabolites From Cyanobacmentioning

confidence: 99%

Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review

et al. 2017

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“…In the last few decades, marine cyanobacteria have been identified as rich prolific producers of natural products, bearing a different structure to plant-derived or synthetic bioactive molecules [1][2][3][4]. Moreover, these products exhibit diverse biological activities, ranging from anticancer to antibiotic activity [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers

Gong²,

Li³

et al. 2020

Marine Drugs

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Jahanyne, a lipopeptide with a unique terminal alkynyl and OEP (2-(1-oxo-ethyl)-pyrrolidine) moiety, exhibits anticancer activity. We synthesized jahanyne and analogs modified at the OEP moiety, employing an α-fluoromethyl ketone (FMK) strategy. Preliminary bioassays indicated that compound 1b (FMK–jahanyne) exhibited decreased activities to varying degrees against most of the cancer cells tested, whereas the introduction of a fluorine atom to the α-position of a hydroxyl group (2b) enhanced activities against all lung cancer cells. Moreover, jahanyne and 2b could induce G0/G1 cell cycle arrest in a concentration-dependent manner.

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“…Two main aspects, the chemical diversity and the related bioactivity, have to be considered when considering the application potential of natural products (molecules, metabolites, or compounds) produced by cyanobacteria. The chemical diversity of metabolites produced by cyanobacteria has been largely described and about fifteen reviews have been already published in the past twenty years dealing with their structural and chemical diversity [9][10][11][12][13][14] or their corresponding biosynthetic pathways [15,16]. Beyond the notorious harmful effects of cyanotoxins, other cyanobacterial natural products show a wide range of bioactivities that could be potentially useful for diverse application fields [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Natural Products from Cyanobacteria: Focus on Beneficial Activities

Demay

Bernard²,

Reinhardt

et al. 2019

Preprint

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Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products (molecules, metabolites, or compounds) that they synthesize support the cyanobacterial success for the colonization of their respective ecological niches. Although cyanobacteria are well-known for their toxin production and their relative deleterious consequences, they also produce a large variety of molecules that exhibit beneficial properties with high potential for various fields of application (e.g., synthetic analog of the dolastatin 10 used against Hodgkin lymphoma). The present review specially focuses on the beneficial activities of cyanobacterial molecules described so far. Based on an analysis of 670 papers, it appears that more than 90 genera of cyanobacteria have been found to produce compounds with potential beneficial activities, most of them belonging to the orders Oscillatoriales, Nostocales Chroococcales, and Synechococcales. The rest of the cyanobacterial orders (i.e., Pleurocapsales, Chroococcidiopsales, and Gloeobacterales) remain poorly explored in terms of their molecular diversity and relative bioactivity. The diverse cyanobacterial molecules presenting beneficial bioactivities belong to 10 different chemical classes (alkaloids, depsipeptides, lipopeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides, and others) that exhibit 14 major kinds of bioactivity. However, no direct relation between the chemical class and the bioactivity of these molecules has been demonstrated. We further selected and specifically described 50 molecule families according to their specific bioactivities and their potential uses in pharmacology, cosmetology, agriculture, or other specific fields of interest. This up-to-date review takes advantage of the recent progresses in genome sequencing and biosynthetic pathway elucidation, and presents new perspectives for the rational discovery of new cyanobacterial metabolites with beneficial bioactivity.

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New Peptides Isolated from Marine Cyanobacteria, an Overview over the Past Decade

Cited by 57 publications

References 88 publications

Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review

Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review

Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers

Natural Products from Cyanobacteria: Focus on Beneficial Activities

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