New Pd/Pt(ii) complexes as unsymmetrical ylide-based chemotherapeutic agents: synthesis, characterization, biological activity, electrochemical, and X-ray studies

Abstract

New P,C-coordinated Pd/Pt-complexes were characterized successfully and the cytotoxic studies showed that they can be used as non-toxic labels for cellular imaging.

Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol

“…The bond lengths of P(2)‐C(26) and P(4)‐C(66) are 1.800(13) Å and 1.783(13) Å, respectively, which is obviously longer compared to the bond length of P−C(H) in the parent ylides such as Ph 2 PCH 2 PPh 2 CH=C(O)C 6 H 4 Ph (1.722(3) Å) . When searching the Cambridge Structural Database (CSD, version 5.40, update Nov 2018) . only two other P−C chelates of phosphorus ylides with Pt are found, i. e. the unsymmetrical phosphorus ylides [PtBr 2 {K 2 (P,C)‐Y}] with Y=[Ph 2 PCH 2 PPh 2 =C(H)C(O)C 6 H 4 ‐ p ‐Ph] and [PtCl 2 {K 2 (P,C)‐Y}] with Y=Ph 2 PCH 2 PPh 2 =C(H)C(O)C 6 H 4 NO 2 …”

Palladium(II)‐Imidoyl Complexes: A New Piece in the Puzzle of Organopalladium Anticancer Agents

“…The organometallic motifs by us so far examined included Pd(II)-allyls, [21][22][23][24][25][26][27] palladacyclopentadienyls, [27,28,29] Pd(0)-olefins [27,30] and more recently Pd(II)-indenyls, [31][32][33] while other research groups turned their attention to Pd(II)-alkynyls [34] and an extensive panel of cyclopalladates. [19,[35][36][37][38] All these works indicate the primary importance of the organic fragment in determining the activity of the complex although it can be modulated by a careful choice of the ancillary ligands. It is therefore a good strategy to endeavour of expanding the library of palladium complexes tested as anti-proliferative agents towards cancer cells, although not being easily able to predict their effectiveness in advance.…”

“…Also our group has been involved in this topic, preparing and testing as anticancer agents, a large number of organopalladium complexes. The organometallic motifs by us so far examined included Pd(II)‐allyls, [21–27] palladacyclopentadienyls, [27,28,29] Pd(0)‐olefins [27,30] and more recently Pd(II)‐indenyls, [31–33] while other research groups turned their attention to Pd(II)‐alkynyls [34] and an extensive panel of cyclopalladates [19,35–38] . All these works indicate the primary importance of the organic fragment in determining the activity of the complex although it can be modulated by a careful choice of the ancillary ligands.…”