New pathogenic insights into rheumatoid arthritis

Jutley, Gurpreet; Raza, Karim; Buckley, Christopher D.

doi:10.1097/bor.0000000000000174

Cited by 39 publications

(25 citation statements)

References 56 publications

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“…Herein we have focused on Helios and Helios-related phenotypes in the context of tissue T reg from rheumatic joints of patients with RA and SpA. These two diseases have overlapping manifestations and similar treatment strategies, but also display different underlying aetiologies [42,43]. Hereby, the commonalities we find are likely to be driven by the local inflammatory environment, and not by the initiating factors for disease occurrence.…”

Section: Discussionmentioning

confidence: 96%

IL-1R1 is expressed on both Helios+ and Helios−FoxP3+CD4+ T cells in the rheumatic joint

Müller

Herrath

Malmström

2015

Clinical and Experimental Immunology

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SummarySynovial fluid from rheumatic joints displays a well-documented enrichment of forkhead box protein 3 (FoxP3)1 regulatory T cells (tissue We also demonstrate a striking enrichment of IL-1R1 expression in synovial CD4 1 T cells that was restricted to the CD25-expressing FoxP3 population, but independent of Helios. IL-1R1 expression appears to define a tissue T reg cell phenotype together with the expression of CD25, glucocorticoid-induced TNF receptor family-related gene (GITR) and CTLA-4.

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Section: Discussionmentioning

confidence: 96%

IL-1R1 is expressed on both Helios+ and Helios−FoxP3+CD4+ T cells in the rheumatic joint

Müller

Herrath

Malmström

2015

Clinical and Experimental Immunology

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“…37 Furthermore, our data on joint complaints was limited. It would have been helpful if more specific RA symptoms were assessed at baseline.…”

Section: Discussionmentioning

confidence: 98%

Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands

et al. 2017

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ObjectivesTo determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the general population.MethodsLifelines is a multidisciplinary prospective population-based cohort study in the Netherlands. Cross-sectional data from 40 136 participants were used. The detection of ACPA was performed by measuring anti-CCP2 on the Phadia-250 analyser with levels ≥6.2 U/mL considered positive. An extensive questionnaire was taken on demographic and clinical information, including smoking, periodontal health and early symptoms of musculoskeletal disorders. RA was defined by a combination of self-reported RA, medication use for the indication of rheumatism and visiting a medical specialist within the last year.ResultsOf the total 40 136 unselected individuals, 401 (1.0%) had ACPA level ≥6.2 U/mL. ACPA positivity was significantly associated with older age, female gender, smoking, joint complaints, RA and first degree relatives with rheumatism. Of the ACPA-positive participants, 22.4% had RA (15.2% had defined RA according to our criteria and 7.2% self-reported RA only). In participants without RA, 311 (0.8%) were ACPA-positive. In the non-RA group, older age, smoking and joint complaints remained significantly more frequently present in ACPA-positive compared with ACPA-negative participants.ConclusionsIn this large population-based study, the prevalence of ACPA levels ≥6.2 U/mL was 1.0% for the total group and 0.8% when excluding patients with RA. Older age, smoking and joint complaints were more frequently present in ACPA-positive Lifelines participants. To our knowledge, this study is the largest study to date on ACPA positivity in the general, mostly Caucasian population.

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“…Rheumatoid arthritis (RA) is an auto-immune disease with unresolved aetiology which predominantly occurs in females (Jutley et al 2015). Glucocorticoids (GCs) have been prescribed for the treatment of RA for decades, and are considered to be effective drugs in reducing inflammation and preventing joint destruction (Hoes et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment

Cuppen

Welsing

et al. 2016

Inflammopharmacol

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ObjectiveAs there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require an adjustment to the treatment strategy for a selection of patients.MethodsSerum samples from 281 RA patients were analysed using a targeted lipidomics platform. The differences in GC use and gender on polar lipid profiles were cross sectionally examined by multiple linear regressions, while correcting for confounding factors.ResultsDifferences in polar lipids between GC users and non-GC users in females and males were merely restricted to lysophospholipids (lysophosphatidylcholines and lysophosphatidylethanolamines). Lysophospholipids in female patients treated with GCs were significantly higher than female patients not treated with GCs (p = 6.0 E−6), whereas no significant difference was observed in male GC users versus non-users (p = 0.397).ConclusionThe lysophospholipid profiles in response to GCs were significantly different between male and female RA patients, which may have implications for the cardiovascular risk of GC treatment.Electronic supplementary materialThe online version of this article (doi:10.1007/s10787-016-0284-1) contains supplementary material, which is available to authorized users.

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New pathogenic insights into rheumatoid arthritis

Cited by 39 publications

References 56 publications

IL-1R1 is expressed on both Helios+ and Helios−FoxP3+CD4+ T cells in the rheumatic joint

IL-1R1 is expressed on both Helios+ and Helios−FoxP3+CD4+ T cells in the rheumatic joint

Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment

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