New Partial Volume Estimation Methods for MRI MP2RAGE

Duché, Quentin; Raniga, Parnesh; Egan, Gary F.; Acosta, Oscar; Gambarota, Giulio; Salvado, Olivier; Saint‐Jalmes, Hervé

doi:10.1007/978-3-319-10443-0_17

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…These effects can be lessened in sub-1 mm isotropic resolution images acquired with high field MRI (Lusebrink et al, 2013 ; Tardif et al, 2015 ). It would also be useful in future implementations of myelinated cortical thickness mapping to correct for partial volume effects using more sophisticated strategies than simply changing the WM fuzzy c-means membership function, as we did in this study (Pham and Bazin, 2004 ; Duche et al, 2014 ; Shafee et al, 2015 ).…”

Section: Discussionmentioning

confidence: 96%

Assessing intracortical myelin in the living human brain using myelinated cortical thickness

et al. 2015

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Alterations in the myelination of the cerebral cortex may underlie abnormal cortical function in a variety of brain diseases. Here, we describe a technique for investigating changes in intracortical myelin in clinical populations on the basis of cortical thickness measurements with magnetic resonance imaging (MRI) at 3 Tesla. For this, we separately compute the thickness of the shallower, lightly myelinated portion of the cortex and its deeper, heavily myelinated portion (referred to herein as unmyelinated and myelinated cortex, respectively). Our expectation is that the thickness of the myelinated cortex will be a specific biomarker for disruptions in myeloarchitecture. We show representative atlases of total cortical thickness, T, unmyelinated cortical thickness, G, and myelinated cortical thickness, M, for a healthy group of 20 female subjects. We further demonstrate myelinated cortical thickness measurements in a preliminary clinical study of 10 bipolar disorder type-I subjects and 10 healthy controls, and report significant decreases in the middle frontal gyrus in T, G, and M in the disorder, with the largest percentage change occurring in M. This study highlights the potential of myelinated cortical thickness measurements for investigating intracortical myelin involvement in brain disease at clinically relevant field strengths and resolutions.

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Section: Discussionmentioning

confidence: 96%

Assessing intracortical myelin in the living human brain using myelinated cortical thickness

et al. 2015

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“…In previous short publications [Duché et al, ], we proposed a new partial volume model to estimate PV from MP2RAGE data. In this model, the parameters contributing to the signal are expressed as the tissue properties

\vec{T} = true{ρ, T_{1}, T_{2}, T_{2}^{*} true}

and the sequence parameters

\vec{Φ}

.…”

Section: Methodsmentioning

confidence: 99%

“…Most models rely on a linear combination of pure tissue signal intensities. Recently, it has been shown that the linear PV model could not be adapted for MP2RAGE data since the bias free image results from a non‐linear combination of two images [Duché et al, ].…”

Section: Introductionmentioning

confidence: 99%

Partial volume model for brain MRI scan using MP2RAGE

Duché

Saint‐Jalmes

Acosta

et al. 2017

Human Brain Mapping

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MP2RAGE is a T1 weighted MRI sequence that estimates a composite image providing much reduction of the receiver bias, has a high intensity dynamic range, and provides an estimate of T1 mapping. It is, therefore, an appealing option for brain morphometry studies. However, previous studies have reported a difference in cortical thickness computed from MP2RAGE compared with widely used Multi-Echo MPRAGE. In this article, we demonstrated that using standard segmentation and partial volume estimation techniques on MP2RAGE introduces systematic errors, and we proposed a new model to estimate partial volume of the cortical gray matter. We also included in their model a local estimate of tissue intensity to take into account the natural variation of tissue intensity across the brain. A theoretical framework is provided and validated using synthetic and physical phantoms. A repeatability experiment comparing MPRAGE and MP2RAGE confirmed that MP2RAGE using our model could be considered for structural imaging in brain morphology study, with similar cortical thickness estimate than that computed with MPRAGE. Hum Brain Mapp 38:5115-5127, 2017. © 2017 Wiley Periodicals, Inc.

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Analysis strategies for high-resolution UHF-fMRI data

et al. 2018

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Functional MRI (fMRI) benefits from both increased sensitivity and specificity with increasing magnetic field strength, making it a key application for Ultra-High Field (UHF) MRI scanners. Most UHF-fMRI studies utilize the dramatic increases in sensitivity and specificity to acquire high-resolution data reaching sub-millimeter scales, which enable new classes of experiments to probe the functional organization of the human brain. This review article surveys advanced data analysis strategies developed for high-resolution fMRI at UHF. These include strategies designed to mitigate distortion and artifacts associated with higher fields in ways that attempt to preserve spatial resolution of the fMRI data, as well as recently introduced analysis techniques that are enabled by these extremely high-resolution data. Particular focus is placed on anatomically-informed analyses, including cortical surface-based analysis, which are powerful techniques that can guide each step of the analysis from preprocessing to statistical analysis to interpretation and visualization. New intracortical analysis techniques for laminar and columnar fMRI are also reviewed and discussed. Prospects for single-subject individualized analyses are also presented and discussed. Altogether, there are both specific challenges and opportunities presented by UHF-fMRI, and the use of proper analysis strategies can help these valuable data reach their full potential.

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New Partial Volume Estimation Methods for MRI MP2RAGE

Cited by 3 publications

References 14 publications

Assessing intracortical myelin in the living human brain using myelinated cortical thickness

Assessing intracortical myelin in the living human brain using myelinated cortical thickness

Partial volume model for brain MRI scan using MP2RAGE

Analysis strategies for high-resolution UHF-fMRI data

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