New parameters for childhood ventilator associated pneumonia diagnosis

İşgüder, Rana; Ceylan, Gökhan; Ağın, Hasan; Gülfidan, Gamze; Ayhan, Fahri Yüce; Devrim, İlker

doi:10.1002/ppul.23504

Cited by 13 publications

(5 citation statements)

References 31 publications

(77 reference statements)

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“…In our study, five biomarkers--s-TREM, SP-D, PTX-3, IL-1β and IL-8--were for the first time simultaneously measured in bronchial aspirates of critically ill children with suspected VAP at two timepoints. Among these biomarkers, s-TREM was evaluated in four studies, three pediatric [20][21][22] and one neonatal [38], with conflicting results concerning the cut-off values of s-TREM for VAP diagnosis. Similarly, SP-D levels in BAL were evaluated in two pediatric studies [14,22] with conflicting conclusions regarding the clinical value of this biomarker.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, there are even fewer data on the role of biomarkers for VAP diagnosis in children. The biomarkers s-TREM and PTX-3 have been investigated in only four pediatric studies with controversial results regarding their diagnostic accuracy [13,[20][21][22], whereas no studies to date exist for the clinical value of IL-1β and IL-8 in early diagnosis of VAP in critically ill children.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Five Host Inflammatory Biomarkers in Early Diagnosis of Ventilator-Associated Pneumonia in Critically Ill Children: A Prospective Single Center Cohort Study

Sdougka,

Simitsopoulou,

Volakli

et al. 2023

Antibiotics

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Background: Early diagnosis of ventilator-associated pneumonia (VAP) remains a challenge due to subjective clinical criteria and the low discriminative power of diagnostic tests. We assessed whether rapid molecular diagnostics in combination with Clinically Pulmonary Index Score (CPIS) scoring, microbiological surveillance and biomarker measurements of PTX-3, SP-D, s-TREM, PTX-3, IL-1β and IL-8 in the blood or lung could improve the accuracy of VAP diagnosis and follow-up in critically ill children. Methods: A prospective pragmatic study in a Pediatric Intensive Care Unit (PICU) was conducted on ventilated critically ill children divided into two groups: high and low suspicion of VAP according to modified Clinically Pulmonary Index Score (mCPIS). Blood and bronchial samples were collected on days 1, 3, 6 and 12 after event onset. Rapid diagnostics were used for pathogen identification and ELISA for PTX-3, SP-D, s-TREM, IL-1β and IL-8 measurements. Results: Among 20 enrolled patients, 12 had a high suspicion (mCPIS > 6), and 8 had a low suspicion of VAP (mCPIS < 6); 65% were male; and 35% had chronic disease. IL-1β levels at day 1 correlated significantly with the number of mechanical ventilation days (rs = 0.67, p < 0.001) and the PICU stay (r = 0.66; p < 0.002). No significant differences were found in the levels of the other biomarkers between the two groups. Mortality was recorded in two patients with high VAP suspicion. Conclusions: PTX-3, SP-D, s-TREM, IL-1β and IL-8 biomarkers could not discriminate patients with a high or low suspicion of VAP diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Five Host Inflammatory Biomarkers in Early Diagnosis of Ventilator-Associated Pneumonia in Critically Ill Children: A Prospective Single Center Cohort Study

Sdougka,

Simitsopoulou,

Volakli

et al. 2023

Antibiotics

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“…Ventilator-associated pneumonia (VAP) is the most common nosocomial pneumonia, occurring two and three days following endotracheal intubation [ 1 ]. VAP is distinguished by having a new progressive infiltrate, alteration in sputum characteristics, high white blood cell count, and high body temperate [ 2 ]. The first five days of intubation are considered the highest risk incidence of VAP, and the mean period from the time of intubation to the development of VAP is four days [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Practice, Compliance, and Barriers toward Ventilator-Associated Pneumonia among Critical Care Nurses in Eastern Mediterranean Region: A Systematic Review

et al. 2022

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Background: Ventilator-associated pneumonia (VAP) has been identified as a serious complication among hospitalized patients and is associated with prolonged hospitalizations and increased costs. The purpose of this study was to examine the knowledge, practices, compliance, and barriers related to ventilator-associated pneumonia among critical care nurses in the eastern Mediterranean region. Methods: The PRISMA guidelines guided this systematic review. Four electronic databases (EMBASE, MEDLINE (via PubMed), SCOPUS, and Web of Science) were used to find studies that were published from 2000 to October 2021. Results: Knowledge of ventilator-associated pneumonia was the highest outcome measure used in 14 of the 23 studies. The review results confirmed that nurses demonstrated low levels of knowledge of ventilator-associated pneumonia, with 11 studies assessing critical care nurses’ compliance with and practice with respect to ventilator-associated pneumonia. Overall, the results showed that most sampled nurses had insufficient levels of compliance with and practices related to ventilator-associated pneumonia. The main barriers reported across the reviewed studies were a lack of education (N = 6), shortage of nursing staff (N = 5), lack of policies and protocols (N = 4), and lack of time (N = 4). Conclusions: The review confirmed the need for comprehensive interventions to improve critical care nurses’ knowledge, compliance, and practice toward ventilator-associated pneumonia. Nurse managers must address barriers that impact nurses’ levels of knowledge, compliance with, and practices related to ventilator-associated pneumonia.

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“…The percentage of pediatric patients requiring Mechanical Ventilation (MV) and hospitalized in ICU varies between 30% and 64%; MV is a life-support therapy aimed at maintaining adequate alveolar ventilation and effective gas exchange in critically ill patients [2] . One of the most commonly associated encountered hospital acquired infections in respiratory Intensive Care Unit is Ventilator Associated Pneumonia (VAP) and it is associated with significant morbidity, mortality and high costs, VAP is defined as nosocomial pneumonia occurring after 48 hours from intubation and mechanical ventilation [3] . In the same context, VAP defined as a respiratory infection caused by micro-aspiration of organisms, 48 hours after going under mechanical ventilation [4] .…”

Section: Introductionmentioning

confidence: 99%

Exploring Risk Factors with Ventilator Associated Pneumonia among Infants in Intensive Care Units

Dagher¹,

Attia

Mahmoud³

et al. 2018

The Medical Journal of Cairo University

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Background: Ventilator Associated Pneumonia (VAP) is defined as pneumonia occurring more than 48 hours after child is intubated and ventilated mechanically; VAP is the second most common hospital-acquired infection in pediatric Intensive Care Units, which linked to increased morbidity, mortality, lengths of stay in the hospital and intensive care unit with high costs. Aim of Study: The current study aimed to explore the risk factors of VAP among infants in Intensive Care Units.

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New parameters for childhood ventilator associated pneumonia diagnosis

Abstract: s-TREM-1 of BALF, serum PCT levels, and CPIS are useful predictors for ventilator-associated pneumonia diagnosis in children. Pediatr Pulmonol. 2017;52:119-128. © 2016 Wiley Periodicals, Inc.

Cited by 13 publications

References 31 publications

Evaluation of Five Host Inflammatory Biomarkers in Early Diagnosis of Ventilator-Associated Pneumonia in Critically Ill Children: A Prospective Single Center Cohort Study

Evaluation of Five Host Inflammatory Biomarkers in Early Diagnosis of Ventilator-Associated Pneumonia in Critically Ill Children: A Prospective Single Center Cohort Study

Knowledge, Practice, Compliance, and Barriers toward Ventilator-Associated Pneumonia among Critical Care Nurses in Eastern Mediterranean Region: A Systematic Review

Exploring Risk Factors with Ventilator Associated Pneumonia among Infants in Intensive Care Units

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