2016
DOI: 10.1073/pnas.1504327113
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New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo

Abstract: The brain is one of the most complex organs, and tools are lacking to assess its cellular morphology in vivo. Here we combine original diffusion-weighted magnetic resonance (MR) spectroscopy acquisition and novel modeling strategies to explore the possibility of quantifying brain cell morphology noninvasively. First, the diffusion of cellspecific metabolites is measured at ultra-long diffusion times in the rodent and primate brain in vivo to observe how cell long-range morphology constrains metabolite diffusio… Show more

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Cited by 90 publications
(155 citation statements)
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References 35 publications
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“…Diffusivity values reported in Table 1 are in very good agreement with those recently extracted from ADC measurements performed at very long t d (and low b) in mouse brain (Table 1 in (17)). However, the only exception is again NAA, for which the estimated D intra here is significantly higher than that reported in (17).…”
Section: Discussionsupporting
confidence: 85%
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“…Diffusivity values reported in Table 1 are in very good agreement with those recently extracted from ADC measurements performed at very long t d (and low b) in mouse brain (Table 1 in (17)). However, the only exception is again NAA, for which the estimated D intra here is significantly higher than that reported in (17).…”
Section: Discussionsupporting
confidence: 85%
“…However, the only exception is again NAA, for which the estimated D intra here is significantly higher than that reported in (17). This difference can be well explained by considering the effect of a slowly diffusing, highly restricted NAA pool on ADC time dependence at long t d .…”
Section: Discussioncontrasting
confidence: 76%
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“…In fact, the values reported in [44,45]. Further studies are needed to establish which underlying biological components give rise to such high µFA in gray matter, but dendrites, astrocyte branches, and nonmyelinated or myelinated axons traversing gray matter could be suspected [93,99]. Time-dependent or spectroscopic experiments on metabolites could provide insight into such questions in the future.…”
Section: Discussionmentioning
confidence: 99%
“…At the extreme end of the spectrum, for structures so short that scriptlDδ, entering into regime C, no curvature is tolerated if the tail q −1 is to appear. These considerations will have to be revisited if one measures the diffusion of molecules other than water, due to differences in their diffusion characteristics [48, 49, 50]. …”
Section: Resultsmentioning
confidence: 99%