New palladium(II) complexes bearing pyrazole-based Schiff base ligands: Synthesis, characterization and cytotoxicity

Platinum(II) and palladium(II) complexes with (N,N′) and (C,N,N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis, characterization and in vitro activities

“…All reactions were carried out with dry and freshly distilled solvents. Column chromatography refers to flash chromatography and was carried out on SiO 2 (13); N(1)\C(1),1.339 (6); N(1)\N(2), 1.370 (6); N(3)\C(7), 1.499 (5); N(3)\C(6), 1.499 (7); N(3)\C(8), 1.506(6); C(1)\C(2), 1.409(8); C (2)\C(3), 1.367(10); C(3)\N(2), 1.349 (7); N(2)\C(5), 1.453(7); C(5)\C(6), 1.483 (7); N (1)\Pt\N(3), 93.57 (15); N(1)\Pt\Cl(1), 176.60 (11), N(3)\Pt\Cl(1), 89.61 (12); N (1)\Pt\Cl(2), 89.32 (12) ). (from 2% to 5%)} to yield 28 mg ( …”

“…In addition, it is well-known that azoles are valuable reagents in coordination chemistry and that their binding to a transition metal ion affects their properties and activities. Few complexes with pyrazole ligands showing an antitumor activity similar to that of cisplatin have been reported [11][12][13][14][15][16][17][18][19][20], but the effect produced by the substituents on the heterocycle has not been clarified so far. Within this therapeutic context, and in order to clarify this point and to elucidate the influence of mode of binding of this family of ligands in the biological activity of the complexes, we decided to synthesize the new pyrazole derivatives 1a-1c ( Fig.…”

Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex

“…The foremost target of most research groups is to find a convenient anticancer drug that can be used efficiently for the treatment of human tumours. In recent years, numerous Pd (II) complexes with promising activity against tumour cell lines have been synthesized and published [2,3]. Importantly, a good relationship was observed between the cytotoxic activity of the Pd complexes and their lypophilicity or solubility [4].…”

Synthesis of Dichloro-Palladium-4-(2,5-Dibromo Imidazolyl)- 2′-Amino Pyridyl Complex As Pre-Catalyst And Its Application In Suzuki-Miyaura Cross Coupling Reaction

“…Abu-Surrah et.al. 10 have recently reported pyrazolebased schiff bases of palladium (II) complex 6, having biological activity. Latestly, M. A. Hashem has reported two dipyridyl-palladium complexes 7 & 8 11 , which are easily prepared in good yield with high purity and promote the SuzukiMiyaura cross coupling reaction.…”