New Oxygenated Africanenes from the Soft Coral Sinularia dissecta

Ramesh, P.; Reddy, N. Srinivasa; Rao, T. Prabhakara; Venkateswarlu, Y.

doi:10.1021/np980449u

Cited by 32 publications

(38 citation statements)

References 10 publications

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“…[49]–[51]), other studies only report the new NP discovered (e.g. [52], [53]). If several publications, from different research groups, report new NP from a particular taxon, it is indicative of the popularity of that taxon.…”

Section: Discussionmentioning

confidence: 99%

Trends in the Discovery of New Marine Natural Products from Invertebrates over the Last Two Decades – Where and What Are We Bioprospecting?

et al. 2012

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It is acknowledged that marine invertebrates produce bioactive natural products that may be useful for developing new drugs. By exploring untapped geographical sources and/or novel groups of organisms one can maximize the search for new marine drugs to treat human diseases. The goal of this paper is to analyse the trends associated with the discovery of new marine natural products from invertebrates (NMNPI) over the last two decades. The analysis considers different taxonomical levels and geographical approaches of bioprospected species. Additionally, this research is also directed to provide new insights into less bioprospected taxa and world regions. In order to gather the information available on NMNPI, the yearly-published reviews of Marine Natural Products covering 1990–2009 were surveyed. Information on source organisms, specifically taxonomical information and collection sites, was assembled together with additional geographical information collected from the articles originally describing the new natural product. Almost 10000 NMNPI were discovered since 1990, with a pronounced increase between decades. Porifera and Cnidaria were the two dominant sources of NMNPI worldwide. The exception was polar regions where Echinodermata dominated. The majority of species that yielded the new natural products belong to only one class of each Porifera and Cnidaria phyla (Demospongiae and Anthozoa, respectively). Increased bioprospecting efforts were observed in the Pacific Ocean, particularly in Asian countries that are associated with the Japan Biodiversity Hotspot and the Kuroshio Current. Although results show comparably less NMNPI from polar regions, the number of new natural products per species is similar to that recorded for other regions. The present study provides information to future bioprospecting efforts addressing previously unexplored taxonomic groups and/or regions. We also highlight how marine invertebrates, which in some cases have no commercial value, may become highly valuable in the ongoing search for new drugs from the sea.

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Section: Discussionmentioning

confidence: 99%

Trends in the Discovery of New Marine Natural Products from Invertebrates over the Last Two Decades – Where and What Are We Bioprospecting?

et al. 2012

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“…In africanane derivatives unsubstituted at C-1, the signal for H-11α always appears at higher fields than the signal for H-11β, usually in the range 0.10 -0.30 ppm. 13,[22][23][24] Based on the same reasoning, the hydroxyl group of 3 should also be α-orientated. At this point, only the stereochemistry of the C-15 methyl group remains to be settled.…”

Section: Resultsmentioning

confidence: 99%

“…22,23 In cis-fused africananes the geminal methyls exhibit similar chemical shifts because each methyl group has one gauche interaction.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition, seasonal variation and a new sesquiterpene alcohol from the essential oil of Lippia integrifolia

Coronel

Cerda-Garcı́a-Rojas

Joseph‐Nathan

et al. 2006

Flavour & Fragrance J

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Chemical investigations on the essential oil of Lippia integrifolia performed by column chromatography, HPLC, GC-MS, 1 H-and 13 C-NMR spectroscopy led to the identification of 78 components. A new sesquiterpene alcohol, trans-africanan-1α α α α α-ol (4), was characterized as a significant component of the oil. Additionally, six samples obtained at monthly intervals through the annual cycle of the shrub (November-April) were studied. The oil was characterized by large amounts of oxygenated sesquiterpenes (53.3 -69.4%) and sesquiterpene hydrocarbons (14.3 -27.9%), along with small amounts of monoterpenoids (1.4-2.9%).Lippifoli-1(6)-en-5-one (2), african-5-en-1α α α α α-ol (3), β β β β β-caryophyllene oxide, 4,5-seco-africanan-4,5-dione (10), trans-africanan-1α α α α α-ol (4), humulene epoxide II, integrifolian-1,5-dione (1) and lippifoli-1(6)-en-4β β β β β-ol-5-one (7) were the main oxygenated constituents. Although the qualitative composition appeared to be constant, there were large quantitative variations in the content of most components through the studied period. Copyright

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“…Two sesquiterpene benzoquinones neopetrosiquinones A (57) and B (58), were reported from the ethanol extract of N. Proxima (Winder et al, 2011). 1, 2-dihydroisoquinoline (59) and isoquinoline-quinone (60) were obtained from the sponge N. similis (Petrosia similis) (Ramesh et al, 1999). (Cerqueira et al, 2003).…”

Section: -Alkylpyridine Alkaloidsmentioning

confidence: 99%

Chemical and bioactive diversities of marine sponge Neopetrosia

Qaralleh

2016

Bangladesh J Pharmacol

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The marine sponge Neopetrosia contains about 27 species that is highly distributed in Indian Ocean, Atlantic Ocean (Caribbean Sea) and Pacific Ocean. It has proven to be valuable to the discovery of medicinal products due to the presence of various types of compounds with variable bio-activities. More than 85 compounds including alkaloids, quinones, sterols and terpenoids were isolated from this genus. Moreover, the crude extracts and the isolated compounds revealed activities such as antimicrobial, anti-fouling, anti-HIV, cytotoxic, anti-tumor, anti-oxidant, anti-protozoal, anti-inflammatory. Because only 9 out of 27 species of the genus Neopetrosia have been chemically studied thus far, there are signiﬁcant opportunities to ﬁnd out new chemical constituents from this genus.

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New Oxygenated Africanenes from the Soft Coral Sinularia dissecta

Abstract: Three new oxygenated africanenes (1-3) have been isolated from the soft coral Sinularia dissecta and were characterized by spectral and chemical studies.

Cited by 32 publications

References 10 publications

Trends in the Discovery of New Marine Natural Products from Invertebrates over the Last Two Decades – Where and What Are We Bioprospecting?

Trends in the Discovery of New Marine Natural Products from Invertebrates over the Last Two Decades – Where and What Are We Bioprospecting?

Chemical composition, seasonal variation and a new sesquiterpene alcohol from the essential oil of Lippia integrifolia

Chemical and bioactive diversities of marine sponge <i>Neopetrosia</i>

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